Evidence map›Paper›PMID 33901584›Full record

ArticleMagnetic resonance imaging2021

Automated, open-source segmentation of the Hippocampus and amygdala with the open Vanderbilt archive of the temporal lobe.

Andrew J Plassard, Shunxing Bao, Maureen McHugo, Lori Beason-Held, Jennifer U Blackford, Stephan Heckers, Bennett A Landman

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew J PlassardVanderbilt University, Computer Science, 2301 Vanderbilt Place, Nashville, TN 37235, USA. Electronic address: andrew.j.plassard@vanderbilt.edu.
Shunxing BaoVanderbilt University, Computer Science, 2301 Vanderbilt Place, Nashville, TN 37235, USA. Electronic address: shunxing.bao@vanderbilt.edu.
Maureen McHugoPsychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, Nashville, TN 37212, USA. Electronic address: maureen.mchugo@vanderbilt.edu.
Lori Beason-HeldLaboratory of Behavioral Neuroscience, National Institute on Aging, NIH, 31 Center Dr, #5C27 MSC 2292, Building 31, Room 5C27, Bethesda, Maryland, 20892-0001, USA. Electronic address: heldlo@grc.nia.nih.gov.
Jennifer U BlackfordPsychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, Nashville, TN 37212, USA. Electronic address: jenni.blackford@vumc.org.
Stephan HeckersPsychiatry and Behavioral Sciences, Vanderbilt University Medical Center, 1601 23rd Avenue South, Nashville, TN 37212, USA. Electronic address: stephan.heckers@vanderbilt.edu.
Bennett A LandmanVanderbilt University, Computer Science, 2301 Vanderbilt Place, Nashville, TN 37235, USA; Vanderbilt University, Electrical Engineering, 2301 Vanderbilt Place, Nashville, TN 37235, USA. Electronic address: bennett.landman@vanderbilt.edu.

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Imaging Hippocampal Function in PsychosisR01MH070560 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HECKERS, STEPHAN · 2005 to 2025
$7.2M
Longitudinal Sub-thalamic Structure and Functional Alterations in Mild Traumatic Brain InjuryR01NS105503 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BADJATIA, NEERAJ, PRINCE, JERRY L · 2018 to 2022
$3.5M
Automatic Cerebellar MRI Labeling In Health and DiseaseR01NS056307 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2006 to 2015
$3.0M
Computer-Assited Functional NeurosurgeryR01NS095291 · NINDS · VANDERBILT UNIVERSITY · PI DAWANT, BENOIT M., DHAESE, PIERRE F. · 2015 to 2018
$2.4M
BIDS: Vanderbilt Training Program in BIg Biomedical Data ScienceT32LM012412 · NLM · VANDERBILT UNIVERSITY · PI BLUME, JEFFREY D., GADD, CYNTHIA S · 2016 to 2020
$1.5M
Neuroimaging and Genetic Study of Inhibited TemperamentK01MH083052 · NIMH · VANDERBILT UNIVERSITY · PI BLACKFORD, JENNIFER URBANO · 2008 to 2012
$718k
Segmentation and volumetric quantification of thalamic nuclei for assessing MSR21NS082891 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2013 to 2014
$425k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NICHD NIH HHS P50 HD103537NIMH NIH HHS K01 MH083052NIMH NIH HHS R01 MH070560NINDS NIH HHS R01 NS056307NINDS NIH HHS R01 NS095291NINDS NIH HHS R01 NS105503NINDS NIH HHS R21 NS082891NLM NIH HHS T32 LM012412
6 · The paper itself

Abstract

Examining volumetric differences of the amygdala and anterior-posterior regions of the hippocampus is important for understanding cognition and clinical disorders. However, the gold standard manual segmentation of these structures is time and labor-intensive. Automated, accurate, and reproducible techniques to segment the hippocampus and amygdala are desirable. Here, we present a hierarchical approach to multi-atlas segmentation of the hippocampus head, body and tail and the amygdala based on atlases from 195 individuals. The Open Vanderbilt Archive of the temporal Lobe (OVAL) segmentation technique outperforms the commonly used FreeSurfer, FSL FIRST, and whole-brain multi-atlas segmentation approaches for the full hippocampus and amygdala and nears or exceeds inter-rater reproducibility for segmentation of the hippocampus head, body and tail. OVAL has been released in open-source and is freely available.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingAmygdalaHippocampusHumansReproducibility of ResultsTemporal LobeAmygdalaHippocampusMulti-atlas segmentationTemporal lobe

Identifiers

PMID33901584
PMCPMC8715642

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.