Evidence map›Paper›PMID 33901518›Full record

ArticleThe Journal of pediatrics2021

Gestational Age, Birth Weight, and Neurocognitive Development in Adolescents in Tanzania.

Nandita Perumal, Karim P Manji, Anne Marie Darling, Rodrick R Kisenge, Ingrid Kvestad, Mari Hysing, David C Belinger, Willy Urassa, Tor A Strand, Christopher P Duggan and 2 more

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nandita PerumalDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address: nperumal@hsph.harvard.edu.
Karim P ManjiDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Anne Marie DarlingDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA.
Rodrick R KisengeDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Ingrid KvestadRegional Center for Child and Youth Mental Health and Child Welfare, NORCE Norwegian Research Center, Bergen, Norway.
Mari HysingDepartment of Psychological Science, Faculty of Psychology, University of Bergen, Bergen, Norway.
David C BelingerDepartment of Neurology, Boston Children's Hospital, Boston, MA.
Willy UrassaDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Tor A StrandDepartment of Research, Innlandet Hospital Trust, Lillehammer, Norway; Faculty of Medicine, Centre for International Health, University of Bergen, Bergen, Norway.
Christopher P DugganDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
A TRAIL OF MICRONUTRIENTS AND ADVERSE PREGNANCY OUTCOMESR01HD037701 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FAWZI, WAFAIE W · 2000 to 2003
$3.8M
A Trial of Zinc and Micronutrients in Tanzanian ChildrenR01HD048969 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI DUGGAN, CHRISTOPHER P · 2006 to 2010
$2.0M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NICHD NIH HHS R01 HD037701NICHD NIH HHS R01 HD048969NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

objectivesTo investigate the association between gestational age, birthweight, and birthweight adjusted for gestational age, with domains of neurocognitive development and behavioral problems in adolescents in Tanzania. STUDY

designData from a long-term follow-up of adolescents aged 11-15 years born to women previously enrolled in a randomized controlled trial of prenatal multiple micronutrient supplementation in Dar es Salaam, Tanzania, were used. A battery of neurodevelopmental tests were administered to measure adolescent general intelligence, executive function, and behavioral problems. The INTERGROWTH-21

resultsAmong adolescents studied (n = 421), higher gestational age (per week), birthweight (per 100 grams), and birthweight for gestational age z-score (per SD) were linearly associated with higher intelligence score (adjusted standardized mean difference, 0.05 SD [95% CI, 0.01-0.09], 0.04 SD [95% CI, 0.02-0.06], and 0.09 SD [95% CI, 0.01-0.17], respectively). Birthweight and birthweight for gestational age z-score, but not gestational age, were also associated with improved executive function. Low birthweight (<2500 g) was associated with lower intelligence and executive function scores. Associations between birthweight and executive function were stronger among adolescents born to women with higher education.

conclusionsThe duration of gestation and birthweight were positively associated with adolescent neurodevelopment in Tanzania. These findings suggest that interventions to improve birth outcomes may also benefit adolescent cognitive function.

Indexed as

Birth WeightGestational AgeAdolescentAdolescent DevelopmentChildCohort StudiesExecutive FunctionFemaleHumansIntelligenceLinear ModelsMaleNeurodevelopmental DisordersTanzania

Identifiers

PMID33901518
PMCPMC8403162

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.