Evidence map›Paper›PMID 33901490›Full record

ArticleThe Journal of biological chemistry

The α3 subunit of GABA

Sven Wagner, ChoongKu Lee, Lucia Rojas, Christian G Specht, JeongSeop Rhee, Nils Brose, Theofilos Papadopoulos

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sven WagnerDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
ChoongKu LeeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Lucia RojasDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Christian G SpechtDiseases and Hormones of the Nervous System (DHNS), Inserm U1195, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
JeongSeop RheeDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Nils BroseDepartment of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Theofilos PapadopoulosDepartment of Molecular Biology, Universitätsmedizin Göttingen, Göttingen, Germany. Electronic address: theofilos.papadopoulos@med.uni-goettingen.de.
Max Planck Institute of Experimental Medicine · DEInserm · FRUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signaling at nerve cell synapses is a key determinant of proper brain function, and synaptic defects-or synaptopathies-are at the basis of many neurological and psychiatric disorders. Collybistin (CB), a brain-specific guanine nucleotide exchange factor, is essential for the formation of γ-aminobutyric acidergic (GABAergic) postsynapses in defined regions of the mammalian forebrain, including the hippocampus and basolateral amygdala. This process depends on a direct interaction of CB with the scaffolding protein gephyrin, which leads to the redistribution of gephyrin into submembranous clusters at nascent inhibitory synapses. Strikingly, synaptic clustering of gephyrin and GABA

Indexed as

AnimalsGABAergic NeuronsHippocampusMembrane ProteinsMiceReceptors, GABA-ASynapsesgephyrinMembrane ProteinsReceptors, GABA-AARHGEF9Gabra1Gabra2Gabra3glycine receptorsGlyRhPEM-2inhibitory synapse

Identifiers

PMID33901490
PMCPMC8141935
OpenAlexW3157596236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.