Evidence map›Paper›PMID 33901429›Full record

ArticleClinica chimica acta; international journal of clinical chemistry2021

Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls.

Maribel Rodríguez-Aguilar, Lorena Díaz de León-Martínez, Blanca Nohemí Zamora-Mendoza, Andreu Comas-García, Sandra Elizabeth Guerra Palomares, Christian Alberto García-Sepúlveda, Luz Eugenia Alcántara-Quintana, Fernando Díaz-Barriga, Rogelio Flores-Ramírez

Abstract read
In one paragraph

Article in Clinica chimica acta; international journal of clinical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maribel Rodríguez-AguilarDepartment of Pharmacy, Health Sciences Division, University of Quintana Roo, Quintana Roo, Mexico.
Lorena Díaz de León-MartínezFaculty of Medicine-Center for Applied Research on Environment and Health (CIAAS), Autonomous University of San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, Mexico.
Blanca Nohemí Zamora-MendozaFaculty of Medicine-Center for Applied Research on Environment and Health (CIAAS), Autonomous University of San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, Mexico.
Andreu Comas-GarcíaCenter for Research in Biomedicine and Health Sciences, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi, SLP, Mexico.
Sandra Elizabeth Guerra PalomaresViral and Human Genomics Laboratory, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi, SLP, Mexico.
Christian Alberto García-SepúlvedaViral and Human Genomics Laboratory, Faculty of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi, SLP, Mexico.
Luz Eugenia Alcántara-QuintanaCONACYT Research Fellow, Coordination for Innovation and Application of Science and Technology (CIACYT), Autonomous University of San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, Mexico.
Fernando Díaz-BarrigaFaculty of Medicine-Center for Applied Research on Environment and Health (CIAAS), Autonomous University of San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, Mexico.
Rogelio Flores-RamírezCONACYT Research Fellow, Coordination for Innovation and Application of Science and Technology (CIACYT), Autonomous University of San Luis Potosí, Avenida Sierra Leona No. 550, CP 78210, Colonia Lomas Segunda Sección, San Luis Potosí, SLP, Mexico. Electronic address: rfloresra@conacyt.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe identified a global chemical pattern of volatile organic compounds in exhaled breath capable of discriminating between COVID-19 patients and controls (without infection) using an electronic nose.

methodsThe study focused on 42 SARS-CoV-2 RT-qPCR positive subjects as well as 42 negative subjects. Principal component analysis indicated a separation of the study groups and provides a cumulative percentage of explanation of the variation of 98.3%.

resultsThe canonical analysis of principal coordinates model shows a separation by the first canonical axis CAP1 (r

conclusionsIn all, the use of olfactory technologies in communities with high transmission rates as well as in resource-limited settings where targeted sampling is not viable represents a practical COVID-19 screening approach capable of promptly identifying COVID-19 suspect patients and providing useful epidemiological information to guide community health strategies in the context of COVID-19.

Indexed as

COVID-19SARS-CoV-2HumansMass ScreeningSensitivity and SpecificityTechnologyAsymptomaticCOVID-19 screeningElectronic noseExhaled breathVolatile organic compounds

Identifiers

PMID33901429
PMCPMC8064814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.