ArticlePLoS genetics2021
Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A two-step auxin-GA cross-talk regulates organ formation in tomato.Development (Cambridge, England) · 2026Article
- Adaptive Mechanisms of White-Flowered Alfalfa (Biology · 2026Article
- Leaf Developmental Stage Influences Disease Resistance in Tomato.Molecular plant pathology · 2025Article
- Phytohormone Crosstalk of Cytokinin Biosynthesis and Signaling Family Genes in Moso Bamboo (International journal of molecular sciences · 2023Article
- The VIL gene CRAWLING ELEPHANT controls maturation and differentiation in tomato via polycomb silencing.PLoS genetics · 2022Article
- Cytokinin-microbiome interactions regulate developmental functions.Environmental microbiome · 2022Article
- Effects of gibberellins on important agronomic traits of horticultural plants.Frontiers in plant science · 2022Review
- Bioimaging tools move plant physiology studies forward.Frontiers in plant science · 2022Article
- Developmental Analysis of Compound Leaf Development inFrontiers in plant science · 2022Article
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Authors and funding
10 authors.
Funding
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Abstract
Morphogenesis and differentiation are important stages in organ development and shape determination. However, how they are balanced and tuned during development is not fully understood. In the compound leaved tomato, an extended morphogenesis phase allows for the initiation of leaflets, resulting in the compound form. Maintaining a prolonged morphogenetic phase in early stages of compound-leaf development in tomato is dependent on delayed activity of several factors that promote differentiation, including the CIN-TCP transcription factor (TF) LA, the MYB TF CLAU and the plant hormone Gibberellin (GA), as well as on the morphogenesis-promoting activity of the plant hormone cytokinin (CK). Here, we investigated the genetic regulation of the morphogenesis-differentiation balance by studying the relationship between LA, CLAU, TKN2, CK and GA. Our genetic and molecular examination suggest that LA is expressed earlier and more broadly than CLAU and determines the developmental context of CLAU activity. Genetic interaction analysis indicates that LA and CLAU likely promote differentiation in parallel genetic pathways. These pathways converge downstream on tuning the balance between CK and GA. Comprehensive transcriptomic analyses support the genetic data and provide insights into the broader molecular basis of differentiation and morphogenesis processes in plants.
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Registered trials
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