Evidence map›Paper›PMID 33901015›Full record

ArticleAging2021

Silencing long noncoding RNA NEAT1 alleviates acute liver failure via the EZH2-mediated microRNA-139/PUMA axis.

Qiang Wang, Shu Liu, Huan Wang, Lian Liu, Sheng Zhang, Yingzi Ming, Yujun Zhao, Ke Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Epigenetic regulation of EZH2 by ncRNAs: mechanisms and oncogenic implications.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qiang WangTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Shu LiuTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Huan WangTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Lian LiuTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Sheng ZhangTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Yingzi MingTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Yujun ZhaoTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Ke ChengTransplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, P.R. China.
Third Xiangya Hospital · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the role of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in the development of ALF. We collected blood samples from patients with acute liver failure (ALF) and established an ALF mouse model induced by D-galactosamine/Lipopolysaccharide (D-GalN/LPS) for

Indexed as

AnimalsEnhancer of Zeste Homolog 2 ProteinGene Expression Regulation, NeoplasticGene SilencingHumansLeukocytes, MononuclearMiceMice, Inbred C57BLMicroRNAsRNA, Long NoncodingTumor Suppressor Protein p53Enhancer of Zeste Homolog 2 ProteinEZH2 protein, humanMicroRNAsMIRN139 microRNA, humanMIRN139 microRNA, mouseNEAT1 long non-coding RNA, humanNEAT1 long non-coding RNA, mouseRNA, Long NoncodingTumor Suppressor Protein p53acute liver failurelong noncoding RNA nuclear enriched abundant transcript 1methylationmicroRNA-139p53-upregulated modulator of apoptosis

Identifiers

PMID33901015
PMCPMC8148447
OpenAlexW3159141712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.