Evidence map›Paper›PMID 33901014›Full record

ArticleAging2021

Balasubramide derivative 3C attenuates atherosclerosis in apolipoprotein E-deficient mice: role of AMPK-STAT1-STING signaling pathway.

Dongcheng Cai, Hongxia Liu, Jing Wang, Yuanlong Hou, Tao Pang, Hansen Lin, Chaoyong He

Open access · greenAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dongcheng CaiState Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Hongxia LiuState Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Jing WangState Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Yuanlong HouJiangsu Province Key Laboratory of Drug Metabolism, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
Tao PangJiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Hansen LinCollege of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Chaoyong HeState Key Laboratory of Natural Medicines, Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
China Pharmaceutical University · CNGuangdong Pharmaceutical University · CNState Key Laboratory of Natural Medicine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously reported the neuroprotective effects of (+)-balasubramide derived compound 3C, but its action on atherosclerosis

Indexed as

AMP-Activated Protein KinasesAnimalsAortaAtherosclerosisDisease Models, AnimalDrug Evaluation, PreclinicalHeterocyclic Compounds, 3-RingHumansInjections, IntraperitonealMaleMembrane ProteinsMiceMice, Knockout, ApoERAW 264.7 CellsSignal TransductionSTAT1 Transcription FactorAMP-Activated Protein KinasesbalasubramideHeterocyclic Compounds, 3-RingMembrane ProteinsStat1 protein, mouseSTAT1 Transcription FactorSting1 protein, mouseSTING ProteinAMPKatherosclerosis(+)-balasubramide derivative 3CSTAT1STING

Identifiers

PMID33901014
PMCPMC8109080
OpenAlexW3158985314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.