Trial reportJournal of medical Internet research2021
The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID-19: Randomized Controlled Trial.
Trial report in Journal of medical Internet research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 8 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- The effects of psychosocial and behavioral interventions on depressive and anxiety symptoms during the COVID-19 pandemic: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Promoting Recovery from Disasters, Pandemics, and Trauma: A Systematic Review of Brief Psychological Interventions to Reduce Distress in Adults, Children, and Adolescents.International journal of environmental research and public health · 2023Pooled it
- Non-Pharmacological Therapies for Post-Viral Syndromes, Including Long COVID: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Guiding future research on psychological interventions in people with COVID-19 and post COVID syndrome and comorbid emotional disorders based on a systematic review.Frontiers in public health · 2023Pooled it
- Online psychosocial interventions for improving mental health in people during the COVID-19 pandemic: A systematic review and meta-analysis.Journal of affective disorders · 2022Pooled it
- Do patients with and survivors of COVID-19 benefit from telerehabilitation? A meta-analysis of randomized controlled trials.Frontiers in public health · 2022Pooled it
- The effectiveness of psychological support interventions for those exposed to mass infectious disease outbreaks: a systematic review.BMC psychiatry · 2021Pooled it
- Effects of mental health interventions among people hospitalized with COVID-19 infection: A systematic review of randomized controlled trials.General hospital psychiatryPooled it
- Long-Term Effectiveness of Unguided Internet-Based Cognitive Behavioral Therapy on Major Depressive Disorder in Chinese Adults: Randomized Controlled Trial With a 12-Month Follow-Up.JMIR mHealth and uHealth · 2026Trial
- Trial
- Effects of cognitive training and group psychotherapy on cognitive performance of post COVID-19 patients: an exploratory and non-randomized clinical trial.European archives of psychiatry and clinical neuroscience · 2024Trial
- A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Depression, anxiety and insomnia among isolated covid-19 patients: tele occupational therapy intervention vs. conventional one: a comparative study.BMC psychology · 2024Trial
- The Effect of Internet-Based Cognitive Behavioral Therapy on Major Depressive Disorder: Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Effect of resistance training on heart rate variability of anxious female college students.Frontiers in public health · 2022Trial
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Effect of Venlafaxine on Inflammatory Level in Patients with Depression.Neuropsychiatric disease and treatment · 2026Article
- Mental health symptoms and associated factors for general population at the stable, recurrence, and end-of-emergency stages of the COVID-19 pandemic: a repeated national cross-sectional study.Epidemiology and psychiatric sciences · 2025Article
- Experiences of Individually Tailored Internet-Based Cognitive Behavioral Therapy During the COVID-19 Pandemic: Qualitative Interview Study.JMIR formative research · 2025Article
- Advancing Mental Health Care: A Comprehensive Review of Digital Tools and Technologies for Enhancing Diagnosis, Treatment, and Wellness.Health care science · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of depressive and anxiety symptoms in patients with COVID-19 is higher than usual. Previous studies have shown that there are drug-to-drug interactions between antiretroviral drugs and antidepressants. Therefore, an effective and safe treatment method was needed. Cognitive behavioral therapy (CBT) is the first-line psychological therapy in clinical treatment. Computerized CBT (cCBT) was proven to be an effective alternative to CBT and does not require face-to-face therapy between a therapist and the patient, which suited the COVID-19 pandemic response.
objectiveThis study aims to evaluate the efficacy of the cCBT program we developed in improving depressive and anxiety symptoms among patients with COVID-19.
methodsWe customized a cCBT program focused on improving depressive and anxiety symptoms among patients with COVID-19, and then, we assessed its effectiveness. Screening was based on symptoms of depression or anxiety for patients who scored ≥7 on the Hamilton Depression Rating Scale (HAMD
resultsThe cCBT + TAU group displayed a significantly decreased score on the HAMD
conclusionsThe findings of this study suggest that the cCBT program we developed was an effective nonpharmacological treatment for symptoms of anxiety, depression, and insomnia among patients with COVID-19. Further research is warranted to investigate the long-term effects of cCBT for symptoms of anxiety, depression, and insomnia in patients with COVID-19.
trial registrationChinese Clinical Trial Registry ChiCTR2000030084; http://www.chictr.org.cn/showprojen.aspx?proj=49952.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.