ArticleThe American journal of psychiatry2021
Neonatal Brain Response to Deviant Auditory Stimuli and Relation to Maternal Trait Anxiety.
Article in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Mismatch Negativity in Autism: Insights Into Predictive Mechanisms.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Longitudinal Changes in Infant Attention-Related Brain Networks and Fearful Temperament.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Precision functional neuroimaging reveals individually specific auditory responses in infants.Developmental cognitive neuroscience · 2026Article
- Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The 'hand-brain-emotion' axis: a theoretical model for handicraft art-based intervention in anxiety disorders through neuroplasticity and autonomic regulation.Frontiers in psychology · 2026Review
- Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants.bioRxiv : the preprint server for biology · 2025Article
- Infants' resting-state functional connectivity and event-related potentials: A multimodal approach to investigating the neural basis of infant novelty detection.Developmental psychology · 2025Article
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Neonatal neural responses to novelty related to behavioral inhibition at 1 year.Developmental psychology · 2024Article
- Precision Functional Mapping to Advance Developmental Psychiatry Research.Biological psychiatry global open science · 2024Review
- Maternal symptoms of depression and anxiety as modifiers of the relationship between prenatal phthalate exposure and infant neurodevelopment in the Atlanta African American maternal-child cohort.Brain, behavior, & immunity - health · 2024Article
- Towards personalized precision functional mapping in infancy.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional parcellation of the neonatal cortical surface.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Functional parcellation of the neonatal brain.bioRxiv : the preprint server for biology · 2023Article
- Baby Brains at Work: How Task-Based Functional Magnetic Resonance Imaging Can Illuminate the Early Emergence of Psychiatric Risk.Biological psychiatry · 2023Review
- Network-specific selectivity of functional connections in the neonatal brain.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- The transition to parenthood in obstetrics: enhancing prenatal care for 2-generation impact.American journal of obstetrics & gynecology MFM · 2022Review
- An ode to fetal, infant, and toddler neuroimaging: Chronicling early clinical to research applications with MRI, and an introduction to an academic society connecting the field.Developmental cognitive neuroscience · 2022Review
- Temperamental risk for anxiety: emerging work on the infant brain and later neurocognitive development.Current opinion in behavioral sciences · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
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Abstract
objectiveExcessive response to unexpected or "deviant" stimuli during infancy and early childhood represents an early risk marker for anxiety disorders. However, research has yet to delineate the specific brain regions underlying the neonatal response to deviant stimuli near birth and the relation to risk for anxiety disorders. The authors used task-based functional MRI (fMRI) to delineate the neonatal response to deviant stimuli and its relationship to maternal trait anxiety.
methodsThe authors used fMRI to measure brain activity evoked by deviant auditory stimuli in 45 sleeping neonates (mean age, 27.8 days; 60% female; 64% African American). In 41 of the infants, neural response to deviant stimuli was examined in relation to maternal trait anxiety on the State-Trait Anxiety Inventory, a familial risk factor for offspring anxiety.
resultsNeonates manifested a robust and widespread neural response to deviant stimuli that resembles patterns found previously in adults. Higher maternal trait anxiety was related to higher responses within multiple brain regions, including the left and right anterior insula, the ventrolateral prefrontal cortex, and multiple areas within the anterior cingulate cortex. These areas overlap with brain regions previously linked to anxiety disorders and other psychiatric illnesses in adults.
conclusionsThe neural architecture sensitive to deviant stimuli robustly functions in newborns. Excessive responsiveness of some circuitry components at birth may signal risk for anxiety and other psychiatric disorders.
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