Evidence map›Paper›PMID 33900443›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021

Topography of choriocapillaris flow deficit predicts development of neovascularization or atrophy in age-related macular degeneration.

Federico Corvi, Giulia Corradetti, Liran Tiosano, John Adam McLaughlin, Thomas K Lee, Srinivas R Sadda

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Relationship between retinal fluid characteristics and vision in neovascular age-related macular degeneration: HARBOR post hoc analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. RPE Curvature Can Screen for Early and Intermediate AMD.Investigative ophthalmology & visual science · 2024
    Article
  15. Observational
  16. Review
  17. The Impact of Diabetic Retinopathy on the Choriocapillaris in Neovascular AMD.Investigative ophthalmology & visual science · 2023
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Federico CorviDoheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Giulia CorradettiDoheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA.
Liran TiosanoDoheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA.
John Adam McLaughlinDepartment of Ophthalmology, Retina Centre of Ottawa, University of Ottawa, Ottawa, ON, Canada.
Thomas K LeeDepartment of Ophthalmology, Retina Centre of Ottawa, University of Ottawa, Ottawa, ON, Canada.
Srinivas R SaddaDoheny Eye Institute, University of California at Los Angeles, Los Angeles, CA, USA. ssadda@doheny.org.ORCID http://orcid.org/0000-0002-4939-3306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the relationship between choriocapillaris (CC), flow deficits (FD), and structural optical coherence tomography (OCT) biomarkers, and the progression of intermediate age-related macular degeneration (iAMD) to complete retinal pigment epithelial and outer retinal atrophy (cRORA) or macular neovascularization (MNV).

methodsConsecutive patients with iAMD were sequentially reviewed to define three equal sized groups: progressed to MNV, progressed to cRORA, or remained stable over 12 months of follow-up. Odds ratios for progression to cRORA and MNV were estimated by logistic regression for intraretinal hyperreflective foci (IHRF), hyporeflective drusen cores (hDC), subretinal drusenoid deposits (SDDs), high central drusen volume, fellow eye with late AMD, and peripheral and central CC FD.

resultsThirty iAMD eyes from 30 patients were enrolled into each group. The CC FD was greater in the peripheral sectors of the macula of eyes which progressed to cRORA compared to the other two groups (P < 0.0001). The central CC FD was also significantly impaired in eyes that progressed to cRORA or MNV compared to eyes that did not progress (P = 0.001 and P = 0.02, respectively). CC FD in the peripheral macula was significantly and independently associated with the development of cRORA, while CC FD in the center was significantly and independently associated with the development of MNV.

conclusionsWhile the CC is diffusely impaired throughout the macula in iAMD eyes that progress to cRORA, it is relatively spared in the more peripheral macula among eyes which progress to MNV. These differential findings may have implications for the pathophysiology of the different late-stage manifestations of AMD.

Indexed as

Macular DegenerationRetinal DrusenAtrophyChoroidFluorescein AngiographyHumansTomography, Optical CoherenceAge-related macular degenerationChoriocapillarisComplete retinal pigment epithelial and outer retinal atrophyMacular neovascularizationOptical coherence tomography angiography

Identifiers

PMID33900443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.