Evidence map›Paper›PMID 33900421›Full record

ArticleArchives of microbiology2021

Contribution of genetic polymorphisms of interleukins IL1B-511 C/T, IL1RN VNTR, IL6-174 G/C, and IL8-251 A/T in gastric lesions: gender and Helicobacter pylori genes matter.

Morgana Maria de Oliveira Barboza, Francivandi Coelho Barbosa, Ana Paula Santos do Carmo, Fernanda Capelo Barroso, Silvia Helena Barem Rabenhorst

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Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Old and New Aspects ofChildren (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Morgana Maria de Oliveira BarbozaDepartment of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil.
Francivandi Coelho BarbosaDepartment of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil.
Ana Paula Santos do CarmoDepartment of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil.
Fernanda Capelo BarrosoDepartment of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil.
Silvia Helena Barem RabenhorstDepartment of Pathology and Forensic Medicine, Federal University of Ceará, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, CE, Brazil. srabenhorst@hotmail.com.ORCID http://orcid.org/0000-0002-5473-4048
Universidade Federal do Ceará · BR

Funding

Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico 13192399-4
6 · The paper itself

Abstract

Stomach pathologies develop in a complex interaction between the host's genetic background and H. pylori virulent genes. Thus, our study aimed to compare active chronic gastritis (ACG), and intestinal metaplasia (IM) with inactive chronic gastritis (ICG), according to interleukin polymorphisms of IL6-174 G/C, IL8-251 A/T, IL1β-511 C/T, and IL1RN VNTR taking into account patient gender and H. pylori genotypes. Interleukin polymorphisms were determined by RFLP-PCR and H. pylori genotype by PCR. IL6-174 GC and IL8-251 T allele showed a protective effect in women against ACG development and, conversely, IL8-251 polymorphism showed a risk for men. More virulent H. pylori strains were associated with the IL8-251 T allele and IL1β-511 T allele in the AGC, and the vacA m1 allele and cagE gene from H. pylori was associated with the IM. Analysis of the progression of gastric lesions must take into account host variability genetic associated with genes H. pylori due to the relation between the virulent H. pylori genes and more severe gastric lesions, besides the relevance to the gender to IL6-174 and IL8-251 polymorphisms.

Indexed as

Helicobacter pyloriInterleukinsPolymorphism, GeneticFemaleGenotypeHelicobacter InfectionsHumansInterleukin-6Interleukin-8MaleStomach NeoplasmsInterleukin-6Interleukin-8InterleukinsGastritisGenderHelicobacter pyloriInterleukinsIntestinal metaplasiaPolymorphisms

Identifiers

PMID33900421
OpenAlexW3159762482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.