Evidence map›Paper›PMID 33900385›Full record

SynthesisBlood advances2021

Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism.

Parth Patel, Payal Patel, Meha Bhatt, Cody Braun, Housne Begum, Robby Nieuwlaat, Rasha Khatib, Carolina C Martins, Yuan Zhang, Itziar Etxeandia-Ikobaltzeta and 20 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Parth PatelDepartment of Medicine, University of Missouri, Kansas City, MO.
Payal PatelDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Meha BhattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Cody BraunDepartment of Medicine, Loyola University Medical Center, Maywood, IL.
Housne BegumDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Robby NieuwlaatDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Rasha KhatibAdvocate Research Institute, Advocate Health Care, Oak Lawn, IL.
Carolina C MartinsDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Yuan ZhangDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Itziar Etxeandia-IkobaltzetaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Jamie VargheseDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Hani AlturkmaniDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Waled BahajDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Mariam BaigDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Rohan KeharDivision of Hematology, Western University, London, ON, Canada.
Ahmad MustafaDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Rakesh PonnapureddyDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Anchal SethiDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Merrill ThomasDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
David WooldridgeDepartment of Emergency Medicine, University of Illinois at Chicago, Chicago, IL.
Wendy LimDepartment of Medicine.
Shannon M BatesDepartment of Medicine.
Eddy LangDepartment of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Grégoire Le GalDepartment of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Linda B HaramatiDepartment of Radiology and.
Jeffrey KlineDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN.
Marc RighiniDivision of Angiology and Hemostasis, Department of Medical Specialties, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; and.
Wojtek WierciochDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Holger SchünemannDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Reem A MustafaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prompt evaluation and therapeutic intervention of suspected pulmonary embolism (PE) are of paramount importance for improvement in outcomes. We systematically reviewed outcomes in patients with suspected PE, including mortality, incidence of recurrent PE, major bleeding, intracranial hemorrhage, and postthrombotic sequelae. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for eligible studies, reference lists of relevant reviews, registered trials, and relevant conference proceedings. We included 22 studies with 15 865 patients. Among patients who were diagnosed with PE and discharged with anticoagulation, 3-month follow-up revealed that all-cause mortality was 5.69% (91/1599; 95% confidence interval [CI], 4.56-6.83), mortality from PE was 1.19% (19/1597; 95% CI, 0.66-1.72), recurrent venous thromboembolism (VTE) occurred in 1.38% (22/1597; 95% CI: 0.81-1.95), and major bleeding occurred in 0.90% (2/221%; 95% CI, 0-2.15). In patients with a low pretest probability (PTP) and negative D-dimer, 3-month follow-up revealed mortality from PE was 0% (0/808) and incidence of VTE was 0.37% (4/1094; 95% CI: 0.007-0.72). In patients with intermediate PTP and negative D-dimer, 3-month follow-up revealed that mortality from PE was 0% (0/2747) and incidence of VTE was 0.46% (14/3015; 95% CI: 0.22-0.71). In patients with high PTP and negative computed tomography (CT) scan, 3-month follow-up revealed mortality from PE was 0% (0/651) and incidence of VTE was 0.84% (11/1302; 95% CI: 0.35-1.34). We further summarize outcomes evaluated by various diagnostic tests and diagnostic pathways (ie, D-dimer followed by CT scan).

Indexed as

Pulmonary EmbolismVenous ThromboembolismHemorrhageHumansIncidenceTomography, X-Ray Computed

Identifiers

PMID33900385
PMCPMC8095140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.