ArticleMolecular systems biology2021
Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- In Silico Mutational Analysis of Two-Component System Genes Associated with Colistin Resistance in ClinicalBiomolecules · 2026Article
- Spatial proximity dictates bacterial competition and expansion in microbial communities.Nature communications · 2025Article
- Understanding the development of bacterial colony: Physiology, new technology, and modeling.Quantitative biology (Beijing, China) · 2025Review
- ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway.Nature chemical biology · 2025Article
- Cyanobacteria and Chloroflexota cooperate to structure light-responsive biofilms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The collapse of cooperation during range expansion of Pseudomonas aeruginosa.Nature microbiology · 2024Article
- Active pH regulation facilitatesmBio · 2024Article
- Mechanism of branching morphogenesis inspired by diatom silica formation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A microtiter peg lid with ziggurat geometry for medium-throughput antibiotic testing andBiofilm · 2023Article
- Swarming ofBiophysics reviews · 2023Review
- Bringing cells to the edge.eLife · 2022Article
- Morphological instability and roughening of growing 3D bacterial colonies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Self-organized canals enable long-range directed material transport in bacterial communities.eLife · 2022Article
- Formation of unique T-shape budding and differential impacts of low surface water on Bacillus mycoides rhizoidal colony.Archives of microbiology · 2022Article
- Advances and challenges in programming pattern formation using living cells.Current opinion in chemical biology · 2022Review
- AI-driven prediction of SARS-CoV-2 variant binding trends from atomistic simulations.The European physical journal. E, Soft matter · 2021Article
- Collective colony growth is optimized by branching pattern formation in Pseudomonas aeruginosa.Molecular systems biology · 2021Article
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Authors and funding
5 authors.
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Abstract
Branching pattern formation is common in many microbes. Extensive studies have focused on addressing how such patterns emerge from local cell-cell and cell-environment interactions. However, little is known about whether and to what extent these patterns play a physiological role. Here, we consider the colonization of bacteria as an optimization problem to find the colony patterns that maximize colony growth efficiency under different environmental conditions. We demonstrate that Pseudomonas aeruginosa colonies develop branching patterns with characteristics comparable to the prediction of modeling; for example, colonies form thin branches in a nutrient-poor environment. Hence, the formation of branching patterns represents an optimal strategy for the growth of Pseudomonas aeruginosa colonies. The quantitative relationship between colony patterns and growth conditions enables us to develop a coarse-grained model to predict diverse colony patterns under more complex conditions, which we validated experimentally. Our results offer new insights into branching pattern formation as a problem-solving social behavior in microbes and enable fast and accurate predictions of complex spatial patterns in branching colonies.
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