ArticleAmerican journal of primatology2021
Age- and cognition-related differences in the gray matter volume of the chimpanzee brain (Pan troglodytes): A voxel-based morphometry and conjunction analysis.
Article in American journal of primatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Brain age gap is associated with cognitive abilities in captive chimpanzees.Scientific reports · 2025Article
- Article
- Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The uniqueness of human vulnerability to brain aging in great ape evolution.Science advances · 2024Article
- The co-activation patterns of multiple brain regions in Juvenile Myoclonic Epilepsy.Cognitive neurodynamics · 2024Review
- Age-related social selectivity: An adaptive lens on a later life social phenotype.Neuroscience and biobehavioral reviews · 2023Review
- Age differences in cortical thickness and their association with cognition in chimpanzee (Pan troglodytes).Neurobiology of aging · 2023Article
- Human and chimpanzee shared and divergent neurobiological systems for general and specific cognitive brain functions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.Neurobiology of aging · 2023Article
- Micro- and macro-changes in early-stage type 2 diabetes mellitus without cognitive impairment: a diffusion tensor imaging (DTI) and surface-based morphometry (SBM) study.Frontiers in neurology · 2023Article
- Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees.Epigenetics · 2022Article
- Age-related brain atrophy in cats without apparent neurological and behavioral signs using voxel-based morphometry.Frontiers in veterinary science · 2022Article
- Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Article
- Neuroanatomical correlates of individual differences in the object choice task in chimpanzees (Frontiers in psychology · 2022Article
- Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates.American journal of primatology · 2021Review
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Several primate species have been shown to exhibit age-related changes in cognition, brain, and behavior. However, severe neurodegenerative illnesses, such as Alzheimer's disease (AD), were once thought to be uniquely human. Recently, some chimpanzees naturally were documented to develop both neurofibrillary tangles and amyloid plaques, the main characteristics of AD pathology. In addition, like humans and other primates, chimpanzees show similar declines in cognition and motor function with age. Here, we used voxel-based morphometry to examine the relationships among gray matter volume, age, and cognition using magnetic resonance imaging scans previously acquired from chimpanzees (N = 216). We first determined the relationship between age and gray matter volume, identifying the regions that declined with age. With a subset of our sample (N = 103), we also determined differences in gray matter volume between older chimpanzees with higher cognition scores than expected for their age, and older chimpanzees with lower than expected scores. Finally, we ran a conjunction analysis to determine any overlap in brain regions between these two analyses. We found that as chimpanzees age, they lose gray matter in regions associated with cognition. In addition, cognitively healthy older chimpanzees (those performing better for their age) have greater gray matter volume in many brain regions compared with chimpanzees who underperform for their age. Finally, the conjunction analysis revealed that regions of age-related decline overlap with the regions that differ between cognitively healthy chimpanzees and those who underperform. This study provides further evidence that chimpanzees are an important model for research on the neurobiology of aging. Future studies should investigate the effects of cognitive stimulation on both cognitive performance and brain structure in aging nonhuman primates.
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