ArticleeLife2021
High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed.
- Estimating the generation time for SARS-CoV-2 transmission using United States household data, December 2021-May 2023.Scientific reports · 2026Article
- Identifying the optimal rapid antigen test for screening and determining the end of isolation: A modeling study.PLoS computational biology · 2026Article
- Mathematical Contact Tracing Models for the COVID-19 Pandemic: A Systematic Review of the Literature.Healthcare (Basel, Switzerland) · 2025Review
- Estimating the generation time for influenza transmission using household data in the United States.Epidemics · 2025Article
- Flexible Bayesian estimation of incubation times.American journal of epidemiology · 2025Article
- Contextual Hospital Conditions and the Risk of Nosocomial SARS-CoV-2 Infection: A Matched Case-Control Study with Density Sampling in a Large Portuguese Hospital.Journal of clinical medicine · 2024Article
- Estimating the generation time for influenza transmission using household data in the United States.medRxiv : the preprint server for health sciences · 2024Article
- Weak Value Amplification Based Optical Sensor for High Throughput Real-Time Immunoassay of SARS-CoV-2 Spike Protein.Biosensors · 2024Article
- Estimating the Epidemic Size of Superspreading Coronavirus Outbreaks in Real Time: Quantitative Study.JMIR public health and surveillance · 2024Article
- Exact calculation of end-of-outbreak probabilities using contact tracing data.Journal of the Royal Society, Interface · 2023Article
- Analysis of the risk and pre-emptive control of viral outbreaks accounting for within-host dynamics: SARS-CoV-2 as a case study.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university community.PLoS pathogens · 2023Article
- Feasibility of using intermittent active monitoring of vital signs by smartphone users to predict SARS-CoV-2 PCR positivity.Scientific reports · 2023Article
- Inferring the differences in incubation-period and generation-interval distributions of the Delta and Omicron variants of SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A multi-strain model with asymptomatic transmission: Application to COVID-19 in the US.Journal of theoretical biology · 2023Article
- Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres: Evaluating the policy for early vaccination of day-care staff in Germany, 2021.Epidemiology and infection · 2023Article
- Extreme differences in SARS-CoV-2 viral loads among respiratory specimen types during presumed pre-infectious and infectious periods.PNAS nexus · 2023Article
- Uncertainty and error in SARS-CoV-2 epidemiological parameters inferred from population-level epidemic models.Journal of theoretical biology · 2023Article
- Modelling the impact of repeat asymptomatic testing policies for staff on SARS-CoV-2 transmission potential.Journal of theoretical biology · 2023Article
- Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Background: Understanding changes in infectiousness during SARS-COV-2 infections is critical to assess the effectiveness of public health measures such as contact tracing. Methods: Here, we develop a novel mechanistic approach to infer the infectiousness profile of SARS-COV-2-infected individuals using data from known infector-infectee pairs. We compare estimates of key epidemiological quantities generated using our mechanistic method with analogous estimates generated using previous approaches. Results: The mechanistic method provides an improved fit to data from SARS-CoV-2 infector-infectee pairs compared to commonly used approaches. Our best-fitting model indicates a high proportion of presymptomatic transmissions, with many transmissions occurring shortly before the infector develops symptoms. Conclusions: High infectiousness immediately prior to symptom onset highlights the importance of continued contact tracing until effective vaccines have been distributed widely, even if contacts from a short time window before symptom onset alone are traced. Funding: Engineering and Physical Sciences Research Council (EPSRC).
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Registered trials
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