Evidence map›Paper›PMID 33899653›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2021

Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments.

Robb Merrill, Henrik Odéen, Christopher Dillon, Rachelle Bitton, Pejman Ghanouni, Allison Payne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Robb MerrillDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7982-2028
Henrik OdéenDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-2055-9795
Christopher DillonSandia National Laboratories, Albuquerque, NM, USA.ORCID 0000-0002-1195-0015
Rachelle BittonDepartment of Radiology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2824-8978
Pejman GhanouniDepartment of Radiology, Stanford University, Stanford, CA, USA.
Allison PayneDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7724-5001
University of Utah · USStanford University · USSandia National Laboratories · US

Funding

Toward the next generation in transcranial MR-guided focused ultrasound: Innovations in thermal and acoustic model-based planning and monitoring for improved safety, efficacy and efficiencyR01EB028316 · NIBIB · UNIVERSITY OF UTAH · PI PARKER, DENNIS L, RIEKE, VIOLA · 2019 to 2022
$2.5M
Siemens MAGNETOM Prisma 3T MRI scannerS10OD018482 · OD · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2015 to 2015
$1.2M
NIBIB NIH HHS R01 EB028316NIH HHS S10 OD018482
6 · The paper itself

Abstract

purposeMagnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and evaluated an open-source, conformable, skin-cooling system for body MRgFUS treatments to reduce skin burns and enable ablation closer to the skin.

methodsA MR-compatible skin cooling system is described that features a conformable skin-cooling pad assembly with feedback control allowing continuous flow and pressure maintenance during the procedure. System performance was evaluated with hydrophone, phantom and

resultsHydrophone studies demonstrated no beam aberration, but a 5-12% reduction of the peak pressure due to the presence of the skin-cooling pad assembly in the acoustic near field. Phantom evaluation demonstrated there is no MR temperature imaging precision reduction or any other artifacts present due to the coolant flow during MRgFUS sonication. The porcine studies demonstrated skin burns were reduced in size or eliminated when compared to the control condition.

conclusionAn open-source design of an MRgFUS active skin cooling system demonstrates device conformability with a reduction of skin burns while ablating superficial tissues.

Indexed as

High-Intensity Focused Ultrasound AblationAnimalsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPhantoms, ImagingSonicationSwinefocused ultrasoundHIFUMRgFUSskin burnsskin cooling

Identifiers

PMID33899653
PMCPMC8925859
OpenAlexW3157478510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.