Evidence map›Paper›PMID 33899571›Full record

ArticleJournal of dental research2021

Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration.

A Binrayes, C Ge, F F Mohamed, R T Franceschi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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  12. Mechanisms during Osteogenic Differentiation in Human Dental Follicle Cells.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

A BinrayesDepartments of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
C GeDepartments of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
F F MohamedDepartments of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
R T FranceschiDepartments of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
YR01DE011723 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 1995 to 2017
$5.3M
Discoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4M
University of Michigan's TMJD and Orofacial Pain Interdisciplinary ConsortiumK12DE023574 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, KAPILA, SUNIL D · 2013 to 2017
$1.8M
Discoidin domain receptor 2, a novel regulator of bone regenerationR21DE029012 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2019 to 2020
$429k
MAP KINASE REGULATION OF OSTEOBLAST FUNCTIONR56DE011723 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2007 to 2007
$286k
NIAMS NIH HHS P30 AR069620NIDCR NIH HHS K12 DE023574NIDCR NIH HHS R01 DE011723NIDCR NIH HHS R01 DE029465NIDCR NIH HHS R21 DE029012NIDCR NIH HHS R56 DE011723
6 · The paper itself

Abstract

Bone loss caused by trauma, neoplasia, congenital defects, or periodontal disease is a major cause of disability and human suffering. Skeletal progenitor cell-extracellular matrix interactions are critical for bone regeneration. Discoidin domain receptor 2 (DDR2), an understudied collagen receptor, plays an important role in skeletal development.

Indexed as

Bone RegenerationDiscoidin Domain Receptor 2SkullAnimalsMiceOsteoblastsX-Ray MicrotomographyDdr2 protein, mouseDiscoidin Domain Receptor 2cell differentiationcell-matrix interactionscollagen receptorcraniofacial biology/geneticsextracellular matrixosteoblasts

Identifiers

PMID33899571
PMCPMC8532241
OpenAlexW3158465443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.