Evidence map›Paper›PMID 33899528›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

Thyroid Function and Mood Disorders: A Mendelian Randomization Study.

Aleksander Kuś, Alisa D Kjaergaard, Eirini Marouli, Fabiola Del Greco M, Rosalie B T M Sterenborg, Layal Chaker, Robin P Peeters, Tomasz Bednarczuk, Bjørn O Åsvold, Stephen Burgess and 4 more

Open access · goldAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Somatic morbidity in bipolar disorders.International journal of bipolar disorders · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 9 countries.

Aleksander KuśDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5422-6900
Alisa D KjaergaardSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-3899-1324
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Fabiola Del Greco MInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lubeck, Bolzano, Italy.
Rosalie B T M SterenborgDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Layal ChakerDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Robin P PeetersDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Tomasz BednarczukDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Bjørn O ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-3837-2101
Stephen BurgessMRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Christina EllervikDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-3088-4375
Marco MediciDepartment of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Erasmus MC · NLMedical University of Warsaw · PLQueen Mary University of London · GBRadboud University Nijmegen · NLEurac Research · ITNorwegian University of Science and Technology · NOSteno Diabetes Centers · DKUniversitätsmedizin Greifswald · DEUniversity of Cambridge · GBUniversity of Copenhagen · DK

Funding

British Heart Foundation CH/12/2/29428British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00002/7Wellcome Trust 204623Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Thyroid Function TestsAdultBipolar DisorderGenome-Wide Association StudyHumansMajor Depressive DisorderMaleMendelian Randomization AnalysisMood DisordersRiskThyroid GlandThyrotropinThyroxineThyrotropinThyroxinebipolar disorderdepressionMendelian randomization studymood disordersnormal-range thyroid functionthyroid

Identifiers

PMID33899528
PMCPMC7612998
OpenAlexW3159901554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.