ArticleJournal of clinical periodontology2021
Dental biofilm of symptomatic COVID-19 patients harbours SARS-CoV-2.
Article in Journal of clinical periodontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05950230 (A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients
Who cites it
21 citing papers in PubMed.
- Extending regular oral hygiene reduces the incidence of upper respiratory symptoms.Brazilian oral research · 2025Trial
- When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies.Infection · 2025Review
- SARS-CoV-2 proteins show great binding affinity to resin composite monomers and polymerized chains.World journal of experimental medicine · 2025Review
- Role of Virus on Oral Biofilm: Inducer or Eradicator?Applied biochemistry and biotechnology · 2024Review
- COVID-19 in Dental Practice Is Prevented by Eugenol Responsible for the Ambient Odor Specific to Dental Offices: Possibility and Speculation.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Review
- Oral Epithelial Cells Expressing Low or Undetectable Levels of Human Angiotensin-Converting Enzyme 2 Are Susceptible to SARS-CoV-2 Virus Infection In Vitro.Pathogens (Basel, Switzerland) · 2023Article
- The Oral Cavity Potentially Serving as a Reservoir for SARS-CoV-2 but Not Necessarily Facilitating the Spread of COVID-19 in Dental Practice.European journal of dentistry · 2023Article
- Impact of DHCWs' Safety Perception on Vaccine Acceptance and Adoption of Risk Mitigation Strategies.JDR clinical and translational research · 2023Article
- Periodontitis and COVID-19: Immunological Characteristics, Related Pathways, and Association.International journal of molecular sciences · 2023Review
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- Microscopic observations of SARS-CoV-2 like particles in different oral samples.European journal of oral sciences · 2022Article
- Covid-19 and SARS-CoV-2 infection in periodontology: A narrative review.Journal of periodontal research · 2022Review
- Post-Operative Bleeding Complications in a Periodontitis Patient Testing Positive for COVID-19.Dentistry journal · 2022Article
- Antiviral effect of mouthwashes against SARS-COV-2: A systematic review.The Saudi dental journal · 2022Review
- SARS CoV-2 load in periodontal disease.Journal of the American Dental Association (1939) · 2022Article
- Biofilms possibly harbor occult SARS-CoV-2 may explain lung cavity, re-positive and long-term positive results.Frontiers in cellular and infection microbiology · 2022Article
- Pros and Cons of CAD/CAM Technology for Infection Prevention in Dental Settings during COVID-19 Outbreak.Sensors (Basel, Switzerland) · 2021Review
- Dentists and doctors need to play on the same team.Nature · 2021Article
- Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells.International journal of molecular sciences · 2021Article
- The Relationships Among Periodontitis, Pneumonia and COVID-19.Frontiers in oral health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
aimsSARS-CoV-2 RNA has been recovered from different sites in the human body, including the mouth. The present study aimed to investigate the presence of SARS-CoV-2 RNA in the dental biofilm of symptomatic patients who tested positive in nasopharyngeal and oropharyngeal (NASO/ORO) samples. MATERIALS &
methodsAn observational clinical study of individuals with flu-like symptoms was conducted between July and September 2020. Dental biofilm (BIO) samples were collected and analysed using real-time quantitative polymerase chain reaction (RT-qPCR) to determine the virus's presence.
resultsSeventy participants (40 ± 9.8 years of age, 71.4% female) tested positive for SARS-CoV-2 RNA in NASO/ORO samples and were included in the study. Among them, 13 tested positive in BIO samples (18.6%; 95% CI: [9.5, 27.7]). The median and interquartile range of cycle quantification (Cq) for NASO/ORO and BIO samples were 15.9 [6.9] and 35.9 [4.0] (p = .001), respectively. BIO-positive participants showed a higher virus load in NASO/ORO samples (p = .012) than those testing negative (Cq = 20.4 [6.1]).
conclusionsDental biofilms from symptomatic COVID-19 patients harbour SARS-CoV-2 RNA and might be a potential reservoir with an essential role in COVID-19 transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.