Evidence map›Paper›PMID 33899229›Full record

ArticleInternational journal of cancer2021

Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study.

Ana-Lucia Mayén, Elom K Aglago, Viktoria Knaze, Reynalda Cordova, Casper G Schalkwijk, Karl-Heinz Wagner, Krasimira Aleksandrova, Veronika Fedirko, Pekka Keski-Rahkonen, Michael F Leitzmann and 18 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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  5. Association between dietary advanced glycation end products and gallstone disease: A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 19 institutions in 10 countries.

Ana-Lucia MayénNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Elom K AglagoNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.ORCID https://orcid.org/0000-0002-0442-3284
Viktoria KnazeNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Reynalda CordovaDepartment of Nutritional Sciences, University of Vienna, Vienna, Austria.
Casper G SchalkwijkDepartment of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, The Netherlands.
Karl-Heinz WagnerDepartment of Nutritional Sciences, University of Vienna, Vienna, Austria.
Krasimira AleksandrovaImmunity and Metabolism Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Veronika FedirkoRollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-7805-9913
Pekka Keski-RahkonenNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.ORCID https://orcid.org/0000-0001-9437-3040
Michael F LeitzmannDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Verena KatzkeDivision of Cancer Epidemiology, Germany Cancer Research Center (DKFZ), Heidelberg, Germany.
Bernard SrourDivision of Cancer Epidemiology, Germany Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network-ISPRO, Florence, Italy.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID https://orcid.org/0000-0003-0122-8624
Salvatore PanicoDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Rosario TuminoCancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy.
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Magritt BrustadDepartment of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Antonio AgudoUnit of Nutrition and Cancer, Catalan Institute of Oncology-ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain.
María Dolores Chirlaque LópezDepartment of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
Pilar AmianoCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Bodil OhlssonDepartment of Internal Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.
Stina RamneNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Elisabete WeiderpassNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.ORCID https://orcid.org/0000-0003-2237-0128
Mazda JenabNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Heinz FreislingNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France.ORCID https://orcid.org/0000-0001-8648-4998
Centre international de recherche sur le cancer · FRGerman Cancer Research Center · DELund University · SEUniversity of Vienna · ATBasque Government · ESEmory University · USFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Institute of Human Nutrition · DEInstitut d'Investigació Biomédica de Bellvitge · ESInstituto Murciano de Investigación Biosanitaria · ESMaastricht University Medical Centre · NLNational Institute for Public Health and the Environment · NLOslo University Hospital · NOPiedmont Reference Center for Epidemiology and Cancer Prevention · ITRegional Health · USUiT The Arctic University of Norway · NOUniversity of Potsdam · DEUniversity of Regensburg · DE

Funding

Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, N

Indexed as

advanced glycation endproductsbile duct cancersEPIC studygallbladder cancerhepatocellular carcinoma

Identifiers

PMID33899229
PMCPMC8360042
OpenAlexW3158384567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.