Evidence map›Paper›PMID 33899122›Full record

ArticleMolecular medicine reports2021

Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes.

Xu-Lan Wang, Wei Zhang, Zhe Li, Wen-Qi Han, Hao-Yu Wu, Qun-Rang Wang, Xin-Hong Liu, Kun Xing, Gong Cheng, Feng-Jun Chang

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. EndothelialCurrent diabetes reviews · 2025
    Review
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xu-Lan WangDepartment of Nursing, Xian'yang Vocational and Technical College, Fengxi New Town United Avenue, Xi'an, Shaanxi 712000, P.R. China.
Wei ZhangDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Zhe LiDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Wen-Qi HanDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Hao-Yu WuDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Qun-Rang WangDepartment of Cardiology, Affiliated Hospital of Shaanxi Traditional Chinese Medicine University, Xianyang, Shaanxi 712000, P.R. China.
Xin-Hong LiuDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Kun XingDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Gong ChengDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Feng-Jun ChangDepartment of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
Shaanxi Provincial People's Hospital · CNAffiliated Hospital of Shaanxi University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide a link between these two diseases. The present study compared the content and function of MPs from patients with ACS with or without T2DM. MPs from healthy subjects (n=20), patients with ACS (n=24), patients with T2DM (n=20) and patients with combined ACS and T2DM (n=24) were obtained. After incubating rat thoracic tissue with MPs, the effect of MPs on endothelial‑dependent vasodilatation, expression of caveolin‑1 and endothelial nitric oxide synthase (

Indexed as

Acute Coronary SyndromeAdultAnimalsCaveolin 1Cell-Derived MicroparticlesCells, CulturedDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHSP90 Heat-Shock ProteinsHumansMaleMiddle AgedNitric OxideNitric Oxide Synthase Type IIICaveolin 1HSP90 Heat-Shock ProteinsNitric OxideNitric Oxide Synthase Type IIIacute coronary syndromecirculating microparticlesendothelial dysfunctionvascular injury

Identifiers

PMID33899122
PMCPMC8097757
OpenAlexW3212260331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.