Evidence map›Paper›PMID 33898918›Full record

ArticleCurrent developments in nutrition2021

INTERGROWTH-21 Identifies High Prevalence of Low Symphysis-Fundal Height in Indigenous Pregnant Women Experiencing Multiple Infections, Nutrient Deficiencies, and Inflammation: The Maternal Infections, Nutrient Deficiencies, and Inflammation (MINDI) Cohort.

Doris González-Fernández, Elizabeta Nemeth, Emérita Del Carmen Pons, Delfina Rueda, Odalis Teresa Sinisterra, Enrique Murillo, Veena Sangkhae, Lisa M Starr, Marilyn E Scott, Kristine G Koski

Open access · goldAbstract read
In one paragraph

Article in Current developments in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Iron and Pregnancy.Advances in experimental medicine and biology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Anemia in Pregnancy With CKD.Kidney international reports · 2024
    Review
  8. Review
  9. Review
  10. Hepcidin and Iron in Health and Disease.Annual review of medicine · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Doris González-FernándezSchool of Human Nutrition, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, Quebec, Canada.ORCID https://orcid.org/0000-0002-1485-9313
Elizabeta NemethCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Emérita Del Carmen PonsDepartment of Nutritional Health, Ministry of Health, Panama City, Panama.
Delfina Rueda"Comarca Ngäbe-Buglé" Health Region, Ministry of Health, San Félix, Chiriquí Province, Panama.
Odalis Teresa Sinisterra"Panamá Norte" Health Region, Ministry of Health, Panama City, Panama.
Enrique MurilloDepartment of Biochemistry, University of Panama, Panama City, Panama.
Veena SangkhaeCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Lisa M StarrInstitute of Parasitology, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, Quebec, Canada.
Marilyn E ScottInstitute of Parasitology, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, Quebec, Canada.
Kristine G KoskiSchool of Human Nutrition, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, Quebec, Canada.
McGill University · CAUniversity of California, Los Angeles · USUniversidad de Panamá · PA

Funding

Iron physiology and pathology in pregnancyR01HD096863 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NEMETH, ELIZABETA · 2019 to 2023
$2.1M
Iron and Pregnancy: Regulatory Mechanisms and Adverse OutcomesK01DK127004 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SANGKHAE, VEENA · 2021 to 2025
$761k
NICHD NIH HHS R01 HD096863NIDDK NIH HHS K01 DK127004
6 · The paper itself

Abstract

backgroundIn the absence of ultrasound, symphysis-fundal height (SFH) can assess maternal-fetal well-being as it is associated with gestational age, fetal weight, and amniotic fluid volume. However, other modifiers of SFH, including maternal infections, nutrient deficiencies, and inflammation (MINDI), have not been widely explored.

objectivesOur objectives were 2-fold:

methodsFor this cross-sectional study, low-SFH-for-gestational-age was assessed using PAHO and INTERGROWTH <10th centile in 174 women at ≥16 weeks of gestation. Bootstrapping selected MINDI variables for inclusion in multivariable fractional polynomial (MFP) logistic regressions for low SFH. Associations of MINDI variables with hepcidin were also investigated.

resultsPrevalence of low SFH was 8% using PAHO, but using INTERGROWTH, 50.6% had SFH <10th centile, including 37.9% <3rd centile. Both PAHO-SFH <10th centile and INTERGROWTH-SFH <3rd centile were associated with higher hepcidin (OR = 1.12,

conclusionsAssociations of low SFH with MINDI variables, including hepcidin, highlight its potential for early detection of multicausal in utero growth faltering.

Indexed as

hepcidinindigenous pregnant womeninflammationINTERGROWTH-21 standardsprotein malnutritionsymphysis–fundal height

Identifiers

PMID33898918
PMCPMC8053398
OpenAlexW3156679671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.