ArticleBioactive materials2021
Three-dimensional-printed individualized porous implants: A new "implant-bone" interface fusion concept for large bone defect treatment.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Patient-specific implants for joint-sparing reconstruction of segmental tibial and femoral defects : systematic literature review and introduction of a classification framework.Bone & joint research · 2026Pooled it
- Systematic Review of joint preservation limb salvage in osteosarcoma around the knee.Frontiers in oncology · 2025Pooled it
- Comparison of clinical efficacy of 3D-printed artificial vertebral body and conventional titanium mesh cage in spinal reconstruction after total en bloc spondylectomy for spinal tumors: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- A novel multifunctional split-type porous biomimetic absorbable mPLA-HA lamina for spinal posterior column reconstruction following laminectomy.Bioactive materials · 2026Article
- A clinically translatable coating-free strategy for 3D-printed porous titanium implants: TiOBioactive materials · 2026Article
- Biomimetic Surface Engineering of Ti-15Zr (Roxolid™) Implants: Enhancing Osseointegration and Bone Regeneration-A Comprehensive Review.Biomimetics (Basel, Switzerland) · 2026Review
- Biodegradable MgBioactive materials · 2026Article
- Comparative study on the efficacy of structural support fixation vs. conventional fixation for depressed tibial plateau fractures.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Article
- Constructing advanced electrospun nanofiber/hydrogel composite scaffolds loading with nano hydroxyapatite and puerarin for promoting osseointegration and osteanagenesis in a rat cranial defect model.Materials today. Bio · 2026Article
- [Preparation andZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Patient-specific Ti-6Al-4V lattice implants for critical-sized, weightbearing limb reconstruction: average 45-month surgical, oncological, and functional follow-up.Bone & joint open · 2026Article
- Mechanical and biological properties of trabecula and strut scaffolds in bone defect reconstruction.BMC biotechnology · 2026Article
- 3D-Printed Titanium Implants with Bioactive Peptide-Polysaccharide Scaffolds for Personalized Bone Reconstruction.Advanced healthcare materials · 2026Article
- Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 2): CT-Based Personalization, Design Workflows and Validation-A Review.Biomimetics (Basel, Switzerland) · 2026Review
- Patient-Specific Lattice Implants for Segmental Femoral and Tibial Reconstruction (Part 1): Defect Patterns, Fixation Strategies and Reconstruction Options-A Review.Biomimetics (Basel, Switzerland) · 2026Review
- Enhanced construct stability with a locking plate system integrated into 3D-printed titanium implants for bone defect reconstruction: a biomechanical comparison of locking versus nonlocking screw fixation.Journal of orthopaedic surgery and research · 2026Article
- Functional personalization in digital manufacturing: a translational framework for patient-specific implants, arthroscopic locators, and therapeutic constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis.Research (Washington, D.C.) · 2026Article
- Design and performance analysis of bionic trabecular bone scaffold structure based on Voronoi.Journal of biological engineering · 2025Article
- 3D-printed models in atlantoaxial surgery training: a comparative study and questionnaire survey.Neurosurgical review · 2025Article
Corrections and comments
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defect repairs are based on bone graft fusion or replacement. Current large bone defect treatments are inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any bone grafts, osteoinductive agents, or surface biofunctionalization to treat large bone defects, and systematically study its long-term therapeutic effects and osseointegration characteristics. Twenty-six patients with large bone defects caused by tumor, infection, or trauma received treatment with individualized porous implants; among them, three typical cases underwent a detailed study. Additionally, a large segmental femur defect sheep model was used to study the osseointegration characteristics. Immediate and long-term biomechanical stability was achieved, and the animal study revealed that the bone grew into the pores with gradual remodeling, resulting in a long-term mechanically stable implant-bone complex. Advantages of 3D-printed microporous implants for the repair of bone defects included 1) that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility, and 2) that osseointegration between the host bone and implants was achieved without bone grafting. Our osseointegration method, in which the "implant-bone" interface fusion concept was used instead of "bone-bone" fusion, subverts the traditional idea of osseointegration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.