Evidence map›Paper›PMID 33898783›Full record

ArticlePhysics and imaging in radiation oncology2021

Exploratory models comparing ethiodized oil-glue and gold fiducials for bladder radiotherapy image-guidance.

Daryl Lim Joon, Alexandra Berlangieri, Benjamin Harris, Mark Tacey, Rachel O'Meara, Brent Pitt, Angela Viotto, Kerryn Brown, Michal Schneider, Nathan Lawrentschuk and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Daryl Lim JoonOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Alexandra BerlangieriOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Benjamin HarrisOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Mark TaceyOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Rachel O'MearaOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Brent PittOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Angela ViottoOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Kerryn BrownOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Michal SchneiderMonash University, Department of Medical Imaging and Radiation Sciences, Faculty of Medicine, Nursing and Health Sciences, Wellington Rd, Clayton, Victoria 3800, Australia.
Nathan LawrentschukOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Shomik SenguptaOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Colleen BerryOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Trish JenkinsOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Michael ChaoOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Morikatsu WadaOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Farshad ForoudiOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Vincent KhooOlivia Newton John Cancer Center, Radiation Oncology, 145 Studley Rd, Heidelberg, Victoria 3084, Australia.
Olivia Newton-John Cancer Wellness & Research Centre · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeImage-guidance with fiducials has been shown to improve pelvic radiotherapy outcome. However, bladder fiducials using ethiodized oil (EO) alone can disperse widely, and gold causes Computed Tomography scan (CT) metal artifacts. The study's purpose was to investigate the ability to deliver EO-tissue glue fiducials and compare them to gold for bladder radiotherapy image guidance. MATERIALS AND

methodsA fluid-filled porcine bladder model was used to assess the ability to cystoscopically inject visible EO glue fiducials into the submucosa. We then transferred the bladders into a porcine pelvis for imaging and compared them to gold fiducials using CT, Cone Beam CT (CBCT), and kilovoltage (KV) planar views. A tissue-equivalent phantom was utilized to analyze the CT number Hounsfield Unit (HU) characteristics and artifacts of the glue and gold fiducials. Percentile ranges and normal tissue voxel percentages of the subsequent CT number voxel histogram from a 2 cm sphere surrounding the fiducial was used to characterize the artifact

resultsWe successfully delivered all EO glue fiducials into the porcine bladders as discrete fiducials. They were well seen on CT, CBCT, and KV imaging. The glue fiducials had lower CT number values, but less CT number spread of the voxel percentile ranges consistent with the diminished contrast and less artifact than gold. The glue fiducial types had similar CT number characteristics.

conclusionThis study has shown that EO glue fiducials can be delivered with online visualization qualities comparable to gold fiducials without metal-related artifacts.

Indexed as

Bladder cancerGlue fiducialsImage-guided radiotherapyLiquid fiducialsProstate cancerRadiotherapy

Identifiers

PMID33898783
PMCPMC8058020
OpenAlexW3127499009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.