ArticleHepatobiliary surgery and nutrition2021
Short- and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma: does left or right side matter?
Article in Hepatobiliary surgery and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Differences in Right Hepatic Duct Length Among Left-Sided Hepatectomies: Conventional Hepatectomy Versus Extended Hepatectomy Versus Trisectionectomy.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Left extended hepatectomy (H123458-B) versus right extended hepatectomy (H145678-B) for hilar cholangiocarcinoma: A single center comparative analysis of surgical outcomes and survival.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Case Report: Fatal mesenteric venous thrombosis and progressive bowel ischemia following right hemihepatectomy.Frontiers in surgery · 2026Article
- Prognostic Impact of Diabetes Mellitus and Extended Hepatectomy on Perihilar Cholangiocarcinoma.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Right-side versus left-side hemihepatectomy for the treatment of Bismuth type IV perihilar cholangiocarcinoma: a comparative study.Frontiers in oncology · 2025Article
- Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible.Annals of surgical oncology · 2024Article
- Parenchyma-Preserving Hepatectomy in Perihilar Cholangiocarcinoma: A Chance for Critical Patients?Visceral medicine · 2024Article
- Clinical feasibility of modified extended left hemihepatectomy in advanced perihilar cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2024Article
- Essential updates 2021/2022: Update in surgical strategy for perihilar cholangiocarcinoma.Annals of gastroenterological surgery · 2023Review
- Gallbladder cancer mimicking perihilar cholangiocarcinoma-considerable rate of postoperative reclassification with implications for prognosis.World journal of surgical oncology · 2023Article
- Perihilar-cholangiocarcinoma: what really matters?Hepatobiliary surgery and nutrition · 2022Article
- Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2022Article
- Editorial on "Hepatobiliary surgery and nutrition · 2022Article
- Review
- Exploring the function of stromal cells in cholangiocarcinoma by three-dimensional bioprinting immune microenvironment model.Frontiers in immunology · 2022Article
- Review
- Surgical Therapy for Perihilar Cholangiocarcinoma: State of the Art.Visceral medicine · 2021Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe only potentially curative option for patients with perihilar cholangiocarcinoma (PHC) is resection, typically an extrahepatic bile duct resection in combination with (extended) liver resection. Complications such as bile leakage and liver failure have been suggested to be more common after right-sided resections compared to left-sided resections, whilst superior oncological outcomes have been reported after right-sided resections. However, data on outcomes after right-sided or left-sided liver resections in PHC are scarce. Therefore, we aimed to investigate short- and long-term outcomes after left and right hemihepatectomy in patients with PHC.
methodsIn this retrospective study, patients undergoing major liver resection for suspected PHC in a tertiary center between 2000-2018 were included. Patients who had undergone left-sided resections were compared to patients with right-sided resections in terms of complications (90-day mortality, overall and severe morbidity and specific complications). For long-term outcomes, only patients with pathologically proven PHC were included in the survival analysis.
resultsA total of 178 patients undergoing hemihepatectomy for suspected PHC were analysed, including 76 left-sided and 102 right-sided resections. Overall 90-day mortality was 14% (24 out of 178), with no significant difference after left-sided resection (11%; 8 out of 76) versus right-sided resection (16%; 16 out of 102) (P=0.319). Severe morbidity (Clavein Dindo ≥3) was also comparable in both groups: 54% versus 61% (P=0.361). No differences in specific complications including bile leakage were observed, although liver failure appeared to occur more frequently after right hemihepatectomy (22% versus 11%, P=0.052). Five-year overall survival for pathologically proven PHC, excluding in-hospital mortality, did not differ; 43.7% after left-sided resection
conclusionsBoth short- and long-term outcomes between patients undergoing left and right hemihepatectomy for PHC were comparable. Post-hepatectomy liver failure was more common after right-sided resection.
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