Evidence map›Paper›PMID 33898330›Full record

ArticleFrontiers in cellular and infection microbiology2021

High Anti-

Clara Mônica F de Lima, Andrea S Magalhães, Rúbia Costa, Carolina C Barreto, Paulo R L Machado, Edgar M Carvalho, Marcus M Lessa, Lucas P Carvalho

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Systemic IgG responses toFrontiers in immunology · 2026
    Article
  5. Review
  6. Article
  7. Performance of Extracellular Vesicles FromJournal of parasitology research · 2025
    Article
  8. Increased Levels of Anti-Antibodies (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Humoral response in Leishmaniasis.Frontiers in cellular and infection microbiology · 2022
    Review
  14. Article
  15. The Presence ofFrontiers in cellular and infection microbiology · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Clara Mônica F de LimaServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Andrea S MagalhãesServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Rúbia CostaServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Carolina C BarretoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Paulo R L MachadoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Edgar M CarvalhoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Marcus M LessaServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Lucas P CarvalhoServiço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Universidade Federal da Bahia · BRComplexo Hospitalar Universitário Professor Edgard Santos · BRFundação Oswaldo Cruz · BR

Funding

Inflammation in the Pathogenesis of Disseminated LeishmaniasisU01AI136032 · NIAID · FEDERAL UNIVERSITY OF BAHIA · PI CARVALHO, EDGAR M · 2017 to 2021
$1.6M
NIAID NIH HHS U01 AI136032
6 · The paper itself

Abstract

Background: Mucosal leishmaniasis (ML), the most inflammatory form of tegumentary leishmaniasis, is predominantly caused by Methods: Patients with a confirmed diagnosis of ML were classified according to clinical staging criteria. Serum levels of Results: Patients in stages IV and V produced higher concentrations of IgG and IgG1 antibodies when compared to those in stage I and II. Significant reductions were seen in the concentrations of IgG and IgG2 antibodies in most patients who responded well to treatment. Conclusions: Our data demonstrate an association between IgG antibody titers and the severity of mucosal disease. The observed reduction in antibody production after successful treatment in most patients preliminarily indicates that these tests can be used to aid in the assessment of therapeutic response.

Indexed as

Leishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousAntibodies, ProtozoanHumansImmunoglobulin GAntibodies, ProtozoanImmunoglobulin GantibodiesIgG subclassesLeishmania braziliensismucosal leishmaniasistherapeutic failure

Identifiers

PMID33898330
PMCPMC8063102
OpenAlexW3156519180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.