ArticleJournal of clinical & translational endocrinology2021
Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia.
Article in Journal of clinical & translational endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Myeloid inflammation thresholds stratify mortality risk in early-stage cardiovascular-kidney-metabolic syndrome: MLR-driven findings from NHANES.Immunologic research · 2025Article
- The effectiveness and safety of specific dietary supplements in modulating uric acid levels, oxidative stress, and lipid metabolism in patients: a network meta-analysis of 13 interventions.Nutrition & metabolism · 2025Article
- Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with metabolic syndrome: the potential role of dipeptidyl peptidase-4.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Evaluating the Prophylactic and Nephroprotective Effects of Vitamin D and Metformin in Diabetic Nephropathy.Oxidative medicine and cellular longevity · 2025Article
- Environmental Triggers of Hyperuricemia and Gout.Rheumatic diseases clinics of North America · 2022Review
- Assessment of causal associations between uric acid and 25-hydroxyvitamin D levels.Frontiers in endocrinology · 2022Article
- Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence.International journal of molecular sciences · 2021Review
- Vitamin D and uric acid: Is parathyroid hormone the missing link?Journal of clinical & translational endocrinology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsVitamin D deficiency is associated with a number of noncommunicable conditions. We conducted a randomised controlled trial to determine the effect of vitamin D supplementation on serum uric acid concentration in patients with prediabetes, in whom hyperuricaemia is common.
methodsSeventy-one volunteers (35-80 years), with impaired fasting glucose and/or impaired glucose tolerance were randomised to three groups, vitamin D
resultsAfter 12 weeks, vitamin D supplementation was associated with a reduction in serum uric acid concentration in participants with baseline uric acid concentration > 6 mg/dL, but no significant change was observed in controls. We then assessed the dose-response relationship between vitamin D supplementation and the change in serum uric acid concentration and found that the change in serum total 25-hydroxyvitamin D did not correlate with the change in serum uric acid that occurred during vitamin D supplementation. The factors associated with larger reductions in serum uric acid were a higher baseline serum uric acid and a larger increase in serum 1,25-dihydroxyvitamin D.
conclusionsVitamin D supplementation lowers serum uric acid in prediabetic patients with hyperuricaemia, and supplementation might be considered to help alleviate hyperuricaemia in these patients
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