Evidence map›Paper›PMID 33898185›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Stretchable, Fully Polymeric Electrode Arrays for Peripheral Nerve Stimulation.

Estelle A Cuttaz, Christopher A R Chapman, Omaer Syed, Josef A Goding, Rylie A Green

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 61 citations in OpenAlex.

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  16. Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology.Journal of visualized experiments : JoVE · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Estelle A CuttazDepartment of Bioengineering Imperial College South Kensington London SW7 2AZ UK.
Christopher A R ChapmanDepartment of Bioengineering Imperial College South Kensington London SW7 2AZ UK.
Omaer SyedDepartment of Bioengineering Imperial College South Kensington London SW7 2AZ UK.
Josef A GodingDepartment of Bioengineering Imperial College South Kensington London SW7 2AZ UK.
Rylie A GreenDepartment of Bioengineering Imperial College South Kensington London SW7 2AZ UK.ORCID 0000-0003-1569-7288
Imperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are composites of conductive polymers in elastomeric matrices that provide both flexibility and enhanced electrochemical properties compared to conventional metallic electrodes. This work focuses on the development of nerve cuff devices and the assessment of the device functionality at each development stage, from CE material to fully polymeric electrode arrays. Two device types are fabricated by laser machining of a thick and thin CE sheet variant on an insulative polydimethylsiloxane substrate and lamination into tubing to produce pre-curled cuffs. Device performance and stability following sterilization and mechanical loading are compared to a state-of-the-art stretchable metallic nerve cuff. The CE cuffs are found to be electrically and mechanically stable with improved charge transfer properties compared to the commercial cuff. All devices are applied to an ex vivo whole sciatic nerve and shown to be functional, with the CE cuffs demonstrating superior charge transfer and electrochemical safety in the biological environment.

Indexed as

DimethylpolysiloxanesElectrodes, ImplantedAnimalsBiocompatible MaterialsElastomersElectric ConductivityEquipment DesignFemaleIn Vitro TechniquesModels, AnimalPolymersRatsRats, Sprague-DawleyReproducibility of ResultsSciatic NerveTranscutaneous Electric Nerve StimulationbaysilonBiocompatible MaterialsDimethylpolysiloxanesElastomersPolymersconductive elastomerconductive polymerelectrode characterizationflexible bioelectronicslaser manufacturingperipheral nerve cuff

Identifiers

PMID33898185
PMCPMC8061359
OpenAlexW3126220186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.