Evidence map›Paper›PMID 33898151›Full record

ArticleCureus2021

Molecular Identification of Human Papillomavirus DNA in Thyroid Neoplasms: Association or Serendipity?

María Ivette Muciño-Hernández, Héctor Montoya-Fuentes, Miguel Ricardo Ochoa-Plascencia, Gonzalo Vázquez-Camacho, Elías Adrián Morales-Jeanhs, Alfonso Enrique Bencomo-Álvarez, Jonathan Matias Chejfec-Ciociano, Clotilde Fuentes-Orozco, Francisco José Barbosa-Camacho, Alejandro González-Ojeda

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

María Ivette Muciño-HernándezMedical Sciences Postgraduate Program, University of Colima, Colima, MEX.
Héctor Montoya-FuentesMolecular Microbiology Laboratory, Biomedical Research Center 01, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Miguel Ricardo Ochoa-PlascenciaBiomedical Sciences Postgraduate Program, Health Sciences University Center, University of Guadalajara, Guadalajara, MEX.
Gonzalo Vázquez-CamachoBasic Science, School of Medicine, Instituto Tecnológico de Estudios Superiores de Monterrey, Monterrey, MEX.
Elías Adrián Morales-JeanhsMolecular Microbiology Laboratory, Biomedical Research Center 01, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Alfonso Enrique Bencomo-ÁlvarezMolecular Microbiology Laboratory, Biomedical Research Center 01, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Jonathan Matias Chejfec-CiocianoBiomedical Research Unit 02, Specialties Hospital - Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Clotilde Fuentes-OrozcoBiomedical Research Unit 02, Specialties Hospital - Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Francisco José Barbosa-CamachoBiomedical Research Unit 02, Specialties Hospital - Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Alejandro González-OjedaBiomedical Research Unit 02, Specialties Hospital - Western National Medical Center, Mexican Institute of Social Security, Guadalajara, MEX.
Mexican Social Security Institute · MXTecnológico de Monterrey · MXUniversidad de Colima · MXUniversidad de Guadalajara · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) is recognized as the most important cofactor in the etiology of cancers of the cervix, esophagus, larynx, and nasopharynx. Experimental evidence suggests that HPV could have an oncogenic influence on thyroid follicular cells; however, to the best of our knowledge, there is no record of its role in human thyroid gland neoplasms.

objectiveThe purpose of this study is to describe the frequency and the types of HPV present in neoplastic thyroid tissue by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

methodsOver 157 samples were analyzed of paraffin-embedded tissue from malignant and benign thyroid tumors. All the paraffin blocks were selected consecutively from the Pathology Tissue Bank archive of the Western Medical Center. The molecular detection and typing were performed at the Molecular Microbiology Laboratory of the Biomedical Research Center, Mexican Institute of Social Security.

resultsThe frequency of HPV findings was 2.5% (four cases). HPV-6 was found in two cases of thyroid hyperplasia (2.5%), and HPV-33 in two cases of papillary cancer (4.6%).

conclusionThe presence of HPV is not frequent in thyroid neoplasms, at least in the studied population. Due to the low prevalence of this virus in our sample, it is not possible to reach conclusions. Further research is needed.

Indexed as

human papillomaviruspolymerase chain reactionthyroid neoplasms

Identifiers

PMID33898151
PMCPMC8057935
OpenAlexW3152752999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.