ArticleJournal of radiosurgery and SBRT2021
Impact of tissue heterogeneity correction on Gamma Knife stereotactic radiosurgery of acoustic neuromas.
Article in Journal of radiosurgery and SBRT, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Deep Learning-Based Heterogeneity Correction of the Homogeneous Dose Distribution for Single Brain Tumors in Gamma Knife Radiosurgery.Advances in radiation oncology · 2025Article
- Adaptation of dose-prescription for vestibular schwannoma radiosurgery taking body contouring method and heterogeneous material into account.Acta oncologica (Stockholm, Sweden) · 2025Article
- Zap-X Radiosurgery System: Initial Clinical Experience in a Recurrent Gamma Knife Case Series.Cureus · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
PURPOSE/
objectivesTreatment planning systems (TPS) for Gamma Knife stereotactic radiosurgery (GK-SRS) include TMR10 algorithms, which assumes tissue homogeneity equivalent to water, and collapsed-cone convolutional (CCC) algorithms, which accounts for tissue inhomogeneity. This study investigated dosimetric differences between TMR10 and CCC TPS for acoustic neuromas (ANs) treated with GK-SRS. MATERIALS/
methodsA retrospective review of 56 AN treated with GK-SRS was performed. All patients underwent MRI and CT imaging during their initial treatment and were planned using TMR10. Each plan was recalculated with CCC using electron density extracted from CT. Parameters of interest included D
resultsMedian target volume of patients was 1.5 cc (0.3 cc-2.8 cc) with median dose of 12 Gy prescribed to the 50% isodose line. Compared to CCC algorithms, the TMR10 calculated dose was higher: D
conclusionThere was a statistically significant dosimetric differences observed between TMR10 and CCC algorithms for AN GK-SRS, particularly in small and lateralized ANs. It may be important to note these differences when relating GK-SRS with standard heterogeneity-corrected SRS regimens.
Indexed as
Identifiers
33898084PMC8055239W3157809394What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.