Evidence map›Paper›PMID 33898034›Full record

ArticleAnnals of medicine and surgery (2012)2021

Increasing Natural Resistance Associated Macrophage Protein 1 serum level after Miana treatment in BALB/c induced

Titis Dewi Wahyuni, Mochammad Hatta, Agussalim Bukhari, Arif Santoso, Muhammad Nasrum Massi

Open access · diamondAbstract read
In one paragraph

Article in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Decreasing mRNA HMGB1 expression inAnnals of medicine and surgery (2012) · 2023
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  5. Review
  6. In vivo and in vitro inhibition effect of propolis onAnnals of medicine and surgery (2012) · 2022
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Titis Dewi WahyuniDepartment of Internal Medicine Faculty Medicine Universitas Pelita Harapan, Jakarta, Indonesia.
Mochammad HattaDepartment of Molecular Biology and Immunology, Faculty Medicine Universitas Hasanuddin Makassar, Indonesia.
Agussalim BukhariDepartment of Nutrition, Faculty Medicine Universitas Hasanuddin, Makassar, Indonesia.
Arif SantosoDepartment of Pulmonology and Respiration, Faculty Medicine Universitas Hasanuddin, Makassar, Indonesia.
Muhammad Nasrum MassiDepartment of Microbiology, Faculty Medicine Universitas Hasanuddin, Makassar, Indonesia.
Hasanuddin University · IDPelita Harapan University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMiana (

objectiveThe aim of this study is to determine the protein level of Natural Resistance Associated Macrophage Protein 1 (NRAMP1), after administration of Miana extracts in BALB/c mice induced

methodsThis is an experimental study using animal model with post test-only controlled group design. Twenty healthy adult male BALB/c mice were randomly divided into four groups, negative control group (distilled water), Levofloxacin 100 mg/kg, injection intraperitoneal, first treatment group (Miana leaves extract/MLE 510 mg/kg) and second treatment group (Miana + levofloxacin). MLE were administered via gastric gavage for ten consecutive days. The blood was drawn from each mice on the first day, on the eight day of experiment (2 h after treatment), and at 10 days. The blood sample was examined by ELISA to determine the NRAMP1 protein level. Analysis of the number of lung tissue bacteria used Plate count agar to see the growth of

resultsNRAMP1 protein level in BALB/c mice after administration of Miana extract was increased significantly in after 10 days treatment (p < 0.0001). The highest increasing in protein levels was found in treatment group (Miana + levofloxacin) with an increase before treatment 3036,07 to 10010,30 pg/ml after treatment p < 0,0001.

conclusionNRAMP1 protein level in BALB/c mice were highest increasing in protein levels after administration of Miana extract and Levofloxacin compared Miana or Levofloxacin only and clinical impact proved a comparable effect on suppressing

Indexed as

BALB/c miceLevofloxacinMiana leaves extractNRAMP1 protein

Identifiers

PMID33898034
PMCPMC8058902
OpenAlexW3151945895

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.