ArticleAnnals of medicine and surgery (2012)2021
Combination of platelet rich plasma and stromal vascular fraction on the level of vascular endothelial growth factor in rat subjects experiencing deep dermal burn injury.
Article in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Skin graft surgery and its impact on platelet counts in Iranian burn patients: a non-randomized clinical trial.BMC surgery · 2024Trial
- Platelet rich plasma promotes cell migration of adipose-derived stem cells by up-regulation of focal adhesion kinase and paxillin.Regenerative therapy · 2025Article
- Harnessing stromal vascular fraction-based therapies for wound healing: Mechanisms, synergies, and clinical translation.Regenerative therapy · 2025Review
- Topical Application of SVF/PRF in Thermal Injuries-A Retrospective Analysis.Journal of clinical medicine · 2025Article
- Protective Effects of Ellagic Acid Against Arsenic-Induced Hepatotoxicity in Male Wistar Rats: Impact of Heme Oxygenase-1 Upregulation.Food science & nutrition · 2025Article
- Effect of platelet-rich plasma and platelet-rich fibrin on healing of burn wound with dual-species biofilm.The Kaohsiung journal of medical sciences · 2025Article
- Platelet-Rich Plasma in Diabetic Foot Ulcer Healing: Contemplating the Facts.International journal of molecular sciences · 2024Review
- The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Increases Fibroblast Growth Factor 2 and Insulin-Like Growth Factor 1 in Full-Thickness Burns in Animal Model.Annals of burns and fire disasters · 2024Article
- The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Mediates the Inflammatory Process in Deep Dermal Burn Injury.Annals of burns and fire disasters · 2023Article
- Advances and prospects of platelet-rich plasma therapy in veterinary ophthalmology.Veterinary research communications · 2023Review
- Article
- The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Increases Fibroblast Growth Factor 7 and Promotes Angiogenesis in Full Thickness Burn Injury: Rat Experimental Study.Annals of burns and fire disasters · 2023Article
- Effects of Platelet-Rich Plasma (Prp) and Stromal Vascular Fraction (Svf) Addition on Epidermal Growth Factor (Egf) Serum Levels in Full-Thickness Burn Healing in Rats.Annals of burns and fire disasters · 2023Article
- Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial.Medical journal of the Islamic Republic of Iran · 2023Article
- Experimental study on stromal vascular fraction mediated inhibition of skin pigmentation in guinea pigs.Annals of translational medicine · 2022Article
- The effect of stromal vascular fraction and Platelet-Rich Plasma combination on basic Fibroblast Growth Factor serum level during anal trauma healing in a Wistar rat model.Annals of medicine and surgery (2012) · 2022Article
- The effect of Platelet-Rich Plasma and Stromal Vascular Fraction combination on Epidermal Growth Factor serum level for anal trauma healing in the Wistar rat model.Annals of medicine and surgery (2012) · 2021Article
- Effect of erythropoietin administration on expression of mRNA brain-derived Neutrophic factor, levels of stromal cell-derived Factor-1, and neuron specific enolase in brain injury modelAnnals of medicine and surgery (2012) · 2021Article
- Transfer factor treatment in management of peritonitis condition: An experimental study in rat.Annals of medicine and surgery (2012) · 2021Article
- Systemic lidocaine administration influences NF-kβ gene expression, NF-kβ and TNF- α protein levels on BALB/c mice with musculoskeletal injury.Annals of medicine and surgery (2012) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe healing process of burns includes coagulation, inflammation, and remodeling. Vascular endothelial growth factor (VEGF) is involved throughout this healing process. Stem cells from the platelet-rich plasma (PRP) with stromal vascular fraction (SVF) can increase concentrations of growth factors, including VEGF. This is expected to accelerate burn healing. The aim of this study was to determine the effect of a combination of PRP and SVF on VEGF levels in a rats model of deep dermal burn wound healing. MATERIALS AND
methodsThis is an experimental research study in rats using a post-test control group design with 4 groups: A) control, B) Vaseline, C) topical PRP and SVF, and D) PRP and SVF injection. Burn wounds were induced according to the modified Guo method.
resultsIn a rats model of deep dermal wound healing, topical Vaseline significantly increased serum VEGF compared to control. Topical application and injection of stem cells also significantly increased serum VEGF compared to control and Vaseline. The VEGF concentration was significantly higher following injection of PRP and SVF, suggesting that the injection route is more effective at increasing VEGF levels compared to the topical application of stem cells.
conclusionThe combination of PRP and SVF, either by injection or topical application, can increase VEGF levels during the healing process from deep dermal burns.
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