Evidence map›Paper›PMID 33897894›Full record

ArticleTheranostics2021

Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.

Qiang Luo, Panpan Xian, Tian Wang, Shengxi Wu, Tangna Sun, Wenting Wang, Bo Wang, Hao Yang, Yanping Yang, Han Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Qiang LuoMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Panpan XianMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Tian WangMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Shengxi WuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, P. R. China.
Tangna SunDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, P. R. China.
Wenting WangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, P. R. China.
Bo WangMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Hao YangMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Yanping YangMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Han WangDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, P. R. China.
Weiping LiuDepartment of Neurosurgery, Xijing Hospital, Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, P. R. China.
Qianfa LongMini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University. No. 161, West 5th Road, Xincheng District, Xi'an, 710003, P. R. China.
Yan'an University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress is a critical event in neuronal damage following seizures. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been shown to be promising nanotherapeutic agents in neurological disorders. However, the mechanism underlying MSC-EVs therapeutic efficacy for oxidative stress-induced neuronal damage remains poorly understood.

Indexed as

AnimalsAntioxidantsCalciumDisease Models, AnimalExtracellular VesiclesFemaleHippocampusHydrogen PeroxideMesenchymal Stem CellsMiceMice, Inbred C57BLMitochondriaNeuronsNF-E2-Related Factor 2Oxidative StressPregnancyAntioxidantsCalciumHydrogen PeroxideNF-E2-Related Factor 2Reactive Oxygen Speciesextracellular vesicleshippocampal neuronmesenchymal stem cellsoxidative stressseizures

Identifiers

PMID33897894
PMCPMC8058724
OpenAlexW3155787777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.