ArticleFrontiers in immunology2021
Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review.Particle and fibre toxicology · 2024Pooled it
- Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.Particle and fibre toxicology · 2022Pooled it
- Dietary and Nutritional Factors in Systemic Lupus Erythematosus Pathophysiology: A Scoping Review of the Evidence from In Vitro, In Vivo, and Human Studies.Advances in nutrition (Bethesda, Md.) · 2026Article
- Reducing Glucocorticoid Burden in Lupus with Omega-3 Fatty Acids: Docosahexaenoic Acid Augments Prednisone Efficacy in Maintaining Cyclophosphamide-Induced Remission of Preclinical Lupus Nephritis.bioRxiv : the preprint server for biology · 2026Article
- Immunological Mechanisms and Effects of Bacterial Infections in Acute-on-Chronic Liver Failure.Cells · 2025Review
- Subchronic intranasal lipopolysaccharide exposure induces pulmonary autoimmunity and glomerulonephritis in NZBWF1 mice.Autoimmunity · 2024Article
- Regulation of macrophage polarization by targeted metabolic reprogramming for the treatment of lupus nephritis.Molecular medicine (Cambridge, Mass.) · 2024Review
- Crystalline silica-induced pulmonary inflammation and autoimmunity in mature adult NZBW/f1 mice: age-related sensitivity and impact of omega-3 fatty acid intervention.Inhalation toxicology · 2024Article
- Dietary docosahexaenoic acid supplementation inhibits acute pulmonary transcriptional and autoantibody responses to a single crystalline silica exposure in lupus-prone mice.Frontiers in immunology · 2024Article
- Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Review
- New Perspectives on the Associations between Blood Fatty Acids, Growth Parameters, and Cognitive Development in Global Child Populations.Nutrients · 2023Review
- Tertiary lymphoid structures as local perpetuators of organ-specific immune injury: implication for lupus nephritis.Frontiers in immunology · 2023Review
- Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice.Frontiers in immunology · 2023Article
- Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment.Particle and fibre toxicology · 2022Article
- Lipid-based regulators of immunity.Bioengineering & translational medicine · 2022Review
- Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice.Inflammation · 2022Article
- Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus.Frontiers in immunology · 2022Article
- Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice.Frontiers in immunology · 2022Article
- Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity.Frontiers in toxicology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
James J PestkaDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States.
Peyman AkbariDepartment of Food Science and Human Nutrition, East Lansing, MI, United States.
Kathryn A WierengaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Melissa A BatesDepartment of Food Science and Human Nutrition, East Lansing, MI, United States.
Kristen N GilleyDepartment of Food Science and Human Nutrition, East Lansing, MI, United States.
James G WagnerInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Ryan P LewandowskiDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.
Lichchavi D RajasingheDepartment of Food Science and Human Nutrition, East Lansing, MI, United States.
Preeti S ChauhanDepartment of Food Science and Human Nutrition, East Lansing, MI, United States.
Adam L LockDepartment of Animal Science, Michigan State University, East Lansing, MI, United States.
Quan-Zhen LiDepartment of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Jack R HarkemaInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.
Michigan State University · USMichigan Department of Agriculture and Rural Development · USThe University of Texas Southwestern Medical Center · US
Funding
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3MRole of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.R01ES027353 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2017 to 2026
$4.8MOmega-3 Fatty Acid Suppression of Silica-induced Inflammasome Activation in a Novel Alveolar Macrophage ModelF31ES030593 · NIEHS · MICHIGAN STATE UNIVERSITY · PI WIERENGA, KATHRYN ALEXANDRIA · 2019 to 2021
$90kNIEHS NIH HHS F31 ES030593NIEHS NIH HHS R01 ES027353NIEHS NIH HHS T32 ES007255
Abstract
Workplace exposure to respirable crystalline silica dust (cSiO
Indexed as
AnimalsDietary SupplementsDisease Models, AnimalDisease ProgressionFatty Acids, Omega-3FemaleHumansInhalation ExposureLupus Erythematosus, SystemicMiceOccupational DiseasesSilicon DioxideFatty Acids, Omega-3Silicon Dioxideautoantibodydocosahexaenoic acidectopic lymphoid structureglomerulonephritisNZBWF1silicasystemic lupus erythematosusω-3 polyunsaturated fatty acid
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.