Evidence map›Paper›PMID 33897620›Full record

ReviewFrontiers in endocrinology2021

Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders.

Shehla Pervin, Srinivasa T Reddy, Rajan Singh

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shehla PervinDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.
Srinivasa T ReddyDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Rajan SinghDepartment of Obstetrics and Gynecology, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, United States.
University of California, Los Angeles · USCharles R. Drew University of Medicine and Science · US

Funding

Sustaining Faculty Development & Community EngagementS21MD000103 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CARLISLE, DAVID M · 2001 to 2015
$73.9M
Workshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Yong Wu · 2012 to 2026
$60.0M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
Beige Adipocytes and African American Breast TumorsSC1CA232319 · NCI · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI PERVIN, SHEHLA · 2018 to 2021
$1.4M
Follistatin promotes browning and influences energy metabolismSC1AG049682 · NIA · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI SINGH, RAJAN · 2014 to 2017
$1.1M
NCI NIH HHS SC1 CA232319NIA NIH HHS P30 AG031679NIA NIH HHS SC1 AG049682NIMHD NIH HHS S21 MD000103NIMHD NIH HHS U54 MD007598
6 · The paper itself

Abstract

Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases. Obesity develops from chronic imbalance between energy intake and energy expenditure. Stimulation of cellular energy burning process has the potential to dissipate excess calories in the form of heat

Indexed as

Adipose Tissue, BeigeAdipose Tissue, BrownAnimalsEnergy MetabolismFibronectinsFollistatinFollistatin-Related ProteinsHumansLigandsMetabolic DiseasesMiceMyostatinObesitySignal TransductionThermogenesisTransforming Growth Factor beta1FibronectinsFNDC5 protein, humanFollistatinFollistatin-Related ProteinsLigandsMSTN protein, humanMyostatinTGFB1 protein, humanTransforming Growth Factor beta1UCP1 protein, humanUncoupling Protein 1adipose tissuefollistatinmyostatinobesitytransforming growth Factor βUCP1

Identifiers

PMID33897620
PMCPMC8062757
OpenAlexW3152786655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.