Evidence map›Paper›PMID 33897612›Full record

ArticleFrontiers in neurology2021

Gene-Environment Interactions in Progressive Supranuclear Palsy.

Irene Litvan, James A Proudfoot, Eden R Martin, David Standaert, David Riley, Deborah Hall, Connie Marras, Ece Bayram, Richard M Dubinsky, Yvette Bordelon and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 2 countries.

Irene LitvanDepartment of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, La Jolla, CA, United States.
James A ProudfootClinical and Translational Research Institute, University of California, San Diego, La Jolla, CA, United States.
Eden R MartinJohn P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, United States.
David StandaertDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
David RileyInMotion, Warrensville Heights, OH, United States.
Deborah HallDepartment of Neurological Sciences, Rush University, Chicago, IL, United States.
Connie MarrasMorto and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Research, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
Ece BayramDepartment of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, La Jolla, CA, United States.
Richard M DubinskyDepartment of General Neurology, University of Kansas Medical Center, Kansas City, KS, United States.
Yvette BordelonDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, United States.
Stephen ReichDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States.
David ShprecherBanner Sun Health Research Institute, Sun City, AZ, United States.
Benzi KlugerDepartment of Neurology, University of Colorado, Denver, CO, United States.
Christopher CunninghamDivision of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, United States.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, United States.
University of California, San Diego · USBanner Sun Health Research Institute · USBaylor College of Medicine · USRush University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of Colorado Denver · USUniversity of Kansas Medical Center · USUniversity of Louisville · USUniversity of Maryland, Baltimore · USUniversity of Miami · USUniversity of Pennsylvania · USUniversity of Toronto · CA

Funding

Genetic and Environmental Risk Factors for PSPR01AG024040 · NIA · UNIVERSITY OF LOUISVILLE · PI LITVAN, IRENE · 2006 to 2010
$2.7M
NIA NIH HHS R01 AG024040
6 · The paper itself

Abstract

Several genetic and environmental factors have been reported in progressive supranuclear palsy (PSP), although none were identified as a definitive cause. We aimed to explore potential gene-environment interactions in PSP. Two hundred and ninety two PSP cases and 292 controls matched for age, sex, and race from the ENGENE-PSP were analyzed to determine the association between PSP and minor alleles of 5 single nucleotide polymorphisms (SNPs) in 4 genes (MAPT, MOBP, EIF2AK3, and STX6), which were previously associated with PSP risk. Interactions between these SNPs and environmental factors, including previously reported occupational and agricultural risk factors for PSP, were assessed for PSP odds and age of symptom onset. Minor alleles of MAPTrs242557 and EIF2AK3rs7571971 were individually associated with increased odds; MAPTrs8070723 minor alleles were associated with lower PSP odds. There were several gene-environment interactions for PSP odds and age of symptom onset, however, they did not remain significant after FDR-correction. Larger scale studies are required to determine potential interactions.

Indexed as

environmentepidemiologygeneprogressive supranuclear palsyrisk factors

Identifiers

PMID33897612
PMCPMC8062875
OpenAlexW3156660215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.