ArticleFrontiers in physiology2021
Vulnerable Plaque Is More Prevalent in Male Individuals at High Risk of Stroke: A Propensity Score-Matched Study.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Sex differences in features of atherosclerotic plaques as revealed by various imaging techniques: historical review.Frontiers in physiology · 2025Review
- Application of machine learning algorithms in predicting carotid artery plaques using routine health assessments.Frontiers in cardiovascular medicine · 2024Article
- Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke.Frontiers in neurology · 2024Article
- Interleukin-6 and thyroid-stimulating hormone index predict plaque stability in carotid artery stenosis: analyses by lasso-logistic regression.Frontiers in cardiovascular medicine · 2024Article
- Serum neurofilament light chain levels are associated with early neurological deterioration in minor ischemic stroke.Frontiers in neurology · 2023Article
- Sex-specific association between inflammation and endothelial function relevant gene and vulnerable carotid plaque.Frontiers in physiology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the gender differences in the prevalence of carotid vulnerable plaques in high-risk individuals for stroke in a multicenter, cross-sectional study.
methodsIn the year 2015, 18595 residents who were at the age of 40 or older participated in a face-to-face study in eight communities in southwestern China. Totally 2,644 participants at high risk of stroke were enrolled. Before and after propensity score matching (PSM), the prevalence of carotid plaques and vulnerable plaques were compared between men and women. Multivariate analyses were applied to explore the association between the gender and carotid plaques. Stratified analyses and interaction tests were performed to identify factors that might modify the association between the gender and carotid plaques.
resultsAmong 2644 high-risk individuals enrolled, there were 1,202 (45.5%) men and 1442 (54.5%) women. Carotid plaques were detected in 904 (34.2%) participants, while vulnerable plaques were found in 425 (16.1%) participants. Before PSM, carotid plaques were more prevalent in male individuals than the female (36.7% vs. 32.1%,
conclusionMale individuals had a higher risk of vulnerable carotid plaque independent of classical vascular risk factors. Whether there is a gender-specific association between variations in genes related to inflammation, lipid metabolis, and endothelial function and plaque vulnerability needs to be further studied.
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