ArticleFrontiers in physiology2021
Improvement of Vascular Function by Knockdown of Salusin-β in Hypertensive Rats via Nitric Oxide and Reactive Oxygen Species Signaling Pathway.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of anesthesia and measurement site on baseline blood pressure in rats (2021-2024).Open veterinary journal · 2025Article
- Salusin-β, Arterial Stiffness, and Heart Rate Variability Influence the Blood Pressure Response to High-Intensity Interval Training Among Older Adults With Hypertension: A Randomized Control Trial.Health science reports · 2025Article
- Measurement of blood pressure in rats: Invasive or noninvasive methods?Physiological reports · 2024Review
- Downregulation of salusins alleviates hypertrophic cardiomyopathy via attenuating oxidative stress and autophagy.European journal of medical research · 2024Article
- Research Progress on the Correlation Between Hypertension and Gut Microbiota.Journal of multidisciplinary healthcare · 2024Review
- Assessment of Metabolic Syndrome and Kidney and Heart Function in Childhood Cancer Survivors.Children (Basel, Switzerland) · 2023Article
- Mechanisms and clinical implications of endothelium-dependent vasomotor dysfunction in coronary microvasculature.American journal of physiology. Heart and circulatory physiology · 2022Review
- Salusin-β, a TOR2A gene product, promotes proliferation, migration, fibrosis, and calcification of smooth muscle cells and accelerates the imbalance of vasomotor function and vascular remodeling in monocrotaline-induced pulmonary hypertensive rats.Frontiers in pharmacology · 2022Article
- Aldehyde Dehydrogenase 2 (ALDH2) Elicits Protection against Pulmonary Hypertension via Inhibition of ERK1/2-Mediated Autophagy.Oxidative medicine and cellular longevity · 2022Article
- Reactive Oxygen Species Are Essential for Vasoconstriction upon Cold Exposure.Oxidative medicine and cellular longevity · 2021Article
- Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension.Drug design, development and therapy · 2021Article
- Knockdown of Salusin-Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSalusin-β, a multifunctional vasoactive peptide, has a potentially important function in the pathological development of hypertension. However, the exact functional role of salusin-β and the underlying mechanism in this process are still not fully understood. The current study aimed to investigate the effects of silencing salusin-β on vascular function and vascular remodeling, as well as its signaling pathways in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY).
methodsSilencing salusin-β was performed by caudal vein injection of adenovirus expressing salusin-β short hairpin RNA (shRNA). Acetylcholine (ACh)-induced endothelium-dependent relaxation was used to evaluate vasodilator function, and high K
resultsSalusin-β levels in plasma and its protein expression in mesenteric artery (MA), coronary artery (CA), and pulmonary artery (PA) of SHR were higher than those in WKY. The salusin-β level and expression were decreased effectively by salusin-β shRNA. Knockdown of salusin-β decreased arterial blood pressure (ABP) and high K
conclusionThese results indicate that knockdown of salusin-β improves endothelium-dependent vascular relaxation and vascular remodeling and decreases ABP and vasoconstriction in SHR, which might be accomplished by increasing eNOS activation and NO release while inhibiting NAD(P)H oxidase derived-ROS generation. Scavenging salusin-β improves vascular function and then prevents the development and progression of vasculopathy of hypertension.
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