Evidence map›Paper›PMID 33897430›Full record

ArticleFrontiers in pharmacology2021

6'-O-Galloylpaeoniflorin Attenuates Osteoclasto-genesis and Relieves Ovariectomy-Induced Osteoporosis by Inhibiting Reactive Oxygen Species and MAPKs/c-Fos/NFATc1 Signaling Pathway.

Wenjie Liu, Gang Xie, Guixin Yuan, Dantao Xie, Zhen Lian, Zihong Lin, Jiajie Ye, Wenyun Zhou, Weijun Zhou, Henghui Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Wenjie LiuDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Gang XieDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Guixin YuanDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Dantao XieDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Zhen LianDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Zihong LinDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Jiajie YeDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Wenyun ZhouDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Weijun ZhouDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Henghui LiInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Xinjia WangDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Haotian FengGuangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.
Ying LiuInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Guanfeng YaoDepartment of Orthopedics, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Shantou University · CNSecond Affiliated Hospital of Shantou University Medical College · CNShanghai University · CNGuangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests bright prospects of some natural antioxidants in the treatment of osteoporosis. 6'-O-Galloylpaeoniflorin (GPF), an antioxidant isolated from peony roots (one of very widely used Oriental medicines, with various anti-inflammatory, antitumor, and antioxidant activities), shows a series of potential clinical applications. However, its effects on osteoporosis remain poorly investigated. The current study aimed to explore whether GPF can attenuate osteoclastogenesis and relieve ovariectomy-induced osteoporosis via attenuating reactive oxygen species (ROS), and investigate the possible mechanism. After the culture of primary murine bone marrow-derived macrophages/monocytes were induced by the use of macrophage colony-stimulating factor (M-CSF) and the receptor activator of NF-κB ligand (RANKL) and then treated with GPF. Cell proliferation and viability were assessed by Cell Counting Kit-8 (CCK-8) assay. Thereafter, the role of GPF in the production of osteoclasts and the osteogenic resorption of mature osteoclasts were evaluated by tartrate-resistant acid phosphatase (TRAP) staining, podosome belt formation, and resorption pit assay. Western blotting and qRT-PCR examination were performed to evaluate proteins' generation and osteoclast-specific gene levels, respectively. The ROS generation in cells was measured

Indexed as

6′-O-galloylpaeoniflorinMAPKsNFATc1osteoclastosteoporosisreactive oxygen species

Identifiers

PMID33897430
PMCPMC8058459
OpenAlexW3147204354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.