ArticleFrontiers in aging neuroscience2021
Age-Related Memory Impairment and Sex-Specific Alterations in Phosphorylation of the Rpt6 Proteasome Subunit and Polyubiquitination in the Basolateral Amygdala and Medial Prefrontal Cortex.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.Nature communications · 2025Article
- Neurophysiological and other features of working memory in older adults at risk for dementia.Cognitive neurodynamics · 2024Article
- Article
- Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories.PloS one · 2024Article
- Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats.Biology of sex differences · 2023Article
- New perspectives on sex differences in learning and memory.Trends in endocrinology and metabolism: TEM · 2023Review
- Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala.Molecular psychiatry · 2023Article
- Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats.Nutritional neuroscience · 2023Article
- Regional and age-dependent changes in ubiquitination in cellular and mouse models of spinocerebellar ataxia type 3.Frontiers in molecular neuroscience · 2023Article
- The epigenetic role of proteasome subunit RPT6 during memory formation in female rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala.Behavioural brain research · 2022Article
- Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice.Frontiers in aging neuroscience · 2022Article
- Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Proteomic Analysis Reveals Sex-Specific Protein Degradation Targets in the Amygdala During Fear Memory Formation.Frontiers in molecular neuroscience · 2021Article
- A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation.Frontiers in behavioral neuroscience · 2021Article
- Differential impacts of advanced age and sex in age-related trace fear memory impairment in rats.Learning & memory (Cold Spring Harbor, N.Y.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging is marked by an accumulation of damaged and modified brain proteins, and the ubiquitin-proteasome system (UPS) is important for cellular protein degradation. Recent work has established a critical role for the UPS in memory and synaptic plasticity, but the role of the UPS in age-related cognitive decline remains poorly understood. We trained young, middle-aged, and aged male and female rats using trace fear conditioning (TFC) to investigate the effects of age and sex on memory. We then measured markers of UPS-related protein degradation (phosphorylation of the Rpt6 proteasome regulatory subunit and K48-linked polyubiquitination) using western blots. We found that aged males, but not aged females, showed behavioral deficits at memory retrieval. Aged males also displayed reduced phosphorylation of the Rpt6 proteasome subunit and accumulation of K48 in the basolateral amygdala, while aged females displayed a similar pattern in the medial prefrontal cortex. These findings suggest that markers of UPS function are differentially affected by age and sex in a brain region-dependent manner. Together these results provide an important step toward understanding the UPS and circuit-level differences in aging males and females.
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