Evidence map›Paper›PMID 33897363›Full record

ReviewFrontiers in neuroscience2021

The Neurobiology of Zika Virus: New Models, New Challenges.

Luciana Monteiro Moura, Vinicius Leati de Rossi Ferreira, Rafael Maffei Loureiro, Joselisa Péres Queiroz de Paiva, Rafaela Rosa-Ribeiro, Edson Amaro, Milena Botelho Pereira Soares, Birajara Soares Machado

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Evolution of Zika virus inVirus evolution · 2025
    Article
  3. Article
  4. Article
  5. Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Luciana Monteiro MouraHospital Israelita Albert Einstein, São Paulo, Brazil.
Vinicius Leati de Rossi FerreiraHospital Israelita Albert Einstein, São Paulo, Brazil.
Rafael Maffei LoureiroHospital Israelita Albert Einstein, São Paulo, Brazil.
Joselisa Péres Queiroz de PaivaHospital Israelita Albert Einstein, São Paulo, Brazil.
Rafaela Rosa-RibeiroHospital Israelita Albert Einstein, São Paulo, Brazil.
Edson AmaroHospital Israelita Albert Einstein, São Paulo, Brazil.
Milena Botelho Pereira SoaresGonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Bahia, Brazil.
Birajara Soares MachadoHospital Israelita Albert Einstein, São Paulo, Brazil.
Hospital Israelita Albert Einstein · BRServiço Nacional de Aprendizagem Industrial · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Zika virus (ZIKV) attracted attention due to one striking characteristic: the ability to cross the placental barrier and infect the fetus, possibly causing severe neurodevelopmental disruptions included in the Congenital Zika Syndrome (CZS). Few years after the epidemic, the CZS incidence has begun to decline. However, how ZIKV causes a diversity of outcomes is far from being understood. This is probably driven by a chain of complex events that relies on the interaction between ZIKV and environmental and physiological variables. In this review, we address open questions that might lead to an ill-defined diagnosis of CZS. This inaccuracy underestimates a large spectrum of apparent normocephalic cases that remain underdiagnosed, comprising several subtle brain abnormalities frequently masked by a normal head circumference. Therefore, new models using neuroimaging and artificial intelligence are needed to improve our understanding of the neurobiology of ZIKV and its true impact in neurodevelopment.

Indexed as

artificial intelligencebrain abnormalitiescell deathcongenital Zika syndromeneurodevelopmentneuroimagingZika virus

Identifiers

PMID33897363
PMCPMC8059436
OpenAlexW3140079489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.