ReviewFrontiers in neuroscience2021
Suppression of Circadian Timing and Its Impact on the Hippocampus.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus.Hormones and behavior · 2025Article
- Ultrasonic vocalisation rate tracks the diurnal pattern of activity in winter phenotype Djungarian hamsters (Phodopus sungorus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- How did I come to sleep research and stay there?Sleep advances : a journal of the Sleep Research Society · 2024Article
- Gut microbiota regulates circadian oscillation in hepatic ischemia-reperfusion injury-induced cognitive impairment by interfering with hippocampal lipid metabolism in mice.Hepatology international · 2023Article
- Reversible suppression of circadian-driven locomotor rhythms in mice using a gradual fragmentation of the day-night cycle.Scientific reports · 2023Article
- Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition.Acta pharmacologica Sinica · 2023Article
- The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.Neurobiology of aging · 2023Article
- Review
- Circadian activities of the brain MNK-eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions.The European journal of neuroscience · 2022Article
- Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics.Molecular neurodegeneration · 2022Review
- Infra-low frequency neurofeedback and insomnia as a model of CNS dysregulation.Frontiers in human neuroscience · 2022Review
- Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia.Frontiers in integrative neuroscience · 2022Article
- Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues.Translational psychiatry · 2021Article
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Authors and funding
1 author.
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Abstract
In this article, I describe the development of the disruptive phase shift (DPS) protocol and its utility for studying how circadian dysfunction impacts memory processing in the hippocampus. The suprachiasmatic nucleus (SCN) of the Siberian hamster is a labile circadian pacemaker that is easily rendered arrhythmic (ARR) by a simple manipulation of ambient lighting. The DPS protocol uses room lighting to administer a phase-advancing signal followed by a phase-delaying signal within one circadian cycle to suppress clock gene rhythms in the SCN. The main advantage of this model for inducing arrhythmia is that the DPS protocol is non-invasive; circadian rhythms are eliminated while leaving the animals neurologically and genetically intact. In the area of learning and memory, DPS arrhythmia produces much different results than arrhythmia by surgical ablation of the SCN. As I show, SCN ablation has little to no effect on memory. By contrast, DPS hamsters have an intact, but arrhythmic, SCN which produces severe deficits in memory tasks that are accompanied by fragmentation of electroencephalographic theta oscillations, increased synaptic inhibition in hippocampal circuits, and diminished responsiveness to cholinergic signaling in the dentate gyrus of the hippocampus. The studies reviewed here show that DPS hamsters are a promising model for translational studies of adult onset circadian dysfunction in humans.
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