ArticleFrontiers in neuroscience2021
Rethinking the Conditions and Mechanism for Glymphatic Clearance.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mapping the Brain's Glymphatic System.Biomedicines · 2026Review
- Enhancing Athlete Resilience: Preliminary Validation of the Sports Mind Inventory and the Impact of Yoga of Immortals on Sports-Related Stress.Behavioral sciences (Basel, Switzerland) · 2025Article
- Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition.Neuroscience bulletin · 2025Article
- Sleep induced by mechanosensory stimulation provides cognitive and health benefits in Drosophila.Sleep · 2024Article
- Brain clearance is reduced during sleep and anesthesia.Nature neuroscience · 2024Article
- Aquaporin-4 and Parkinson's Disease.International journal of molecular sciences · 2024Review
- Association study of brain structure-function coupling and glymphatic system function in patients with mild cognitive impairment due to Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Whole CNS 3D Cryo-Fluorescence Tomography Shows CSF Clearance along Nasal Lymphatics, Spinal Nerves, and Lumbar/Sacral Lymph Nodes.Journal of imaging · 2023Article
- The influence of physiological and pathological perturbations on blood-brain barrier function.Frontiers in neuroscience · 2023Review
- Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study.Frontiers in aging neuroscience · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Fluid transport in the brain.Physiological reviews · 2022Review
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- Do We Swallow the Waste From Our Brain?Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Critical studies that form the foundation of the glymphatic system and the clearance of metabolic by-products of unwanted proteins from the brain are reviewed. Concerns are raised about studying glymphatic flow in anesthetized animals and making assumptions about the whole brain based upon data collected from a cranial window on the cortex. A new model is proposed arguing that the flow of cerebral spinal fluid and parenchymal clearance in the perivascular system of unwanted proteins is regulated by circadian changes in brain temperature and blood flow at the level of the microvasculature.
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