Evidence map›Paper›PMID 33897286›Full record

ArticleCentral-European journal of immunology2021

Immuno-hormonal network in postmenopausal women: disturbance in breast cancer patients.

Andrew Glushkov, Elena Polenok, Lyudmila Gordeeva, Stella Mun, Mikhail Kostyanko, Alexandr Antonov, Natalia Verzhbitskaya, Ilgiz Vafin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central-European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Andrew GlushkovFederal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo, Russia.
Elena PolenokFederal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo, Russia.
Lyudmila GordeevaFederal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo, Russia.
Stella MunFederal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo, Russia.
Mikhail KostyankoDepartment of Organic and Physical Chemistry, Institute of Fundamental Sciences, Kemerovo State University, Kemerovo, Russia.
Alexandr AntonovDepartment of Mammology, Regional Clinical Oncology Dispensary, Kemerovo, Russia.
Natalia VerzhbitskayaDepartment of Pathoanatomy, Regional Pathologoanatomic Bureaus, Kemerovo, Russia.
Ilgiz VafinRegional Center of Blood, Kemerovo, Russia.
Institute of Coal of the Siberian Branch of the RAS · RUKemerovo Cardiology Center · RUSiberian Branch of the Russian Academy of Sciences · RUKemerovo State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntibodies to estradiol and progesterone (Es and Pg) modulated their blood serum concentration and biological effects in immunized animals. Antibodies to membrane steroid receptors acted as hormone agonists or antagonists in cell cultures. MATERIAL AND

methodsHere we studied the levels of Es and Pg, idiotypic immunoglobulin (Ig) A1 and anti-idiotypic IgG2 specific to Es and Pg in the serum of postmenopausal women (82 healthy donors and 443 breast cancer patients).

resultsIt was found that individual high ratios of Pg/Es (> 4), IgA-Pg1/IgA-Es1 (> 1) and IgG-Pg2/IgG-Es2 (> 1) were associated with low breast cancer risk (OR = 0.4-0.5). High ratios of IgA-Pg1/IgA-Es1 and IgG-Pg2/IgG-Es2 were associated with a high Pg/Es ratio in healthy women but not in breast cancer patients. The levels of idiotypic IgA to benzo[a]pyrene correlated significantly with IgA-Es1 and IgA-Pg1 levels in both compared groups. IgA-Pg1/IgA-Es1 ratio correlated with IgG-Pg2/IgG-Es2 only in healthy women but not in breast cancer patients.

conclusionsThe normal immune-hormonal balance supports the real adaptation of the organism to environmental carcinogens and inhibits the initiation and promotion of carcinogenesis. The disturbance between certain elements of this network (immune-hormonal disbalance) could stimulate carcinogenesis. Further studies of immune-hormonal interaction could be helpful for understanding the pathogenesis of other carcinogen-induced steroid-dependent diseases in humans.

Indexed as

antibodiesbreast cancerestradiolprogesterone

Identifiers

PMID33897286
PMCPMC8056356
OpenAlexW3144012004

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.