ArticleJournal of clinical orthopaedics and trauma2021
Mortality escalates in patients of proximal femoral fractures with COVID-19: A systematic review and meta-analysis of 35 studies on 4255 patients.
Article in Journal of clinical orthopaedics and trauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- The enhancement of medical treatment of proximal femur fracture despite COVID-19 pandemic - a retrospective analysis of a level 1 trauma center.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Increased complications of proximal femur fractures during the COVID-19 pandemic: a nationwide medical claims database study in Japan.Journal of bone and mineral metabolism · 2025Article
- Proximal femoral fractures in patients with COVID-19 : Pneumonia and admission from a nursing home are the strongest predictors of mortality.Zeitschrift fur Gerontologie und Geriatrie · 2024Article
- Postoperative pneumonia after femoral fracture surgery: an in-depth retrospective analysis.BMC musculoskeletal disorders · 2024Article
- Mortality Rate and Outcomes of Omicron Variant Positive Patients with Osteoporotic Fractures: A Retrospective Study.Journal of bone metabolism · 2024Article
- COVID-19 hip fracture outcomes: The role of Ct values and D-dimer levels?Journal of orthopaedic translation · 2023Article
- Effectiveness of patient triage at the orthopedic hospital and the hygiene concept in a professional handball team in the first year of the SARS-CoV-2 pandemic.Orthopadie (Heidelberg, Germany) · 2023Review
- Comparing the 30-Day Mortality for Hip Fractures in Patients with and without COVID-19: An Updated Meta-Analysis.Journal of personalized medicine · 2023Article
- Coronavirus Disease 2019 and the Injured Patient: A Multicenter Review.The Journal of surgical research · 2022Article
- Effects of COVID-19 confinement on the incidence and mortality of major osteoporotic fractures: an observational study in Catalonia, Spain.Archives of osteoporosis · 2022Observational
- Letter to the Editor: "Failure to Medically Optimize Before Total Hip Arthroplasty: Which Modifiable Risk Factor Is the Most Dangerous?"Arthroplasty today · 2021Article
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConcerns have been raised about the escalated mortality in patients of proximal femoral fractures (PPFs) with COVID-19. A meta-analysis to evaluate the mortality in patients with PPFs managed during the current COVID-19 pandemic was conducted.
methodsA systematic review and meta-analysis of all published studies were conducted with a search on PubMed, Scopus, Web of Science, and Cochrane Library databases using appropriate keywords from January 01, 2020 to January 29, 2021.
results35 relevant studies reporting 4255 patients with hip fracture in the current ongoing pandemic, out of which 692 patients were COVID-19 positive. Twenty studies reported mortality and other relevant statistics on hip fracture patients with and without COVID-19 (4123 hip fracture patients in the year 2020-21, out of which 560 had or were suspected of having COVID -19). A meta-analysis of mortality statistics in patients with and without COVID revealed increased odds of mortality among COVID patients [odds ratio (OR) 6.31, 95% confidence interval (CI) [5.09, 7.83] and meta-analysis on the subgroup of surgically treated patients also showed markedly increased mortality risk among those with COVID-19 (OR) 5.99, 95% CI [3.88,9.24].
conclusionThe mortality risk is markedly increased in hip fracture with concomitant COVID-19 as compared to those without it. This increased risk persisted in those managed surgically. It could be due to the inflammation induced by the fracture or surgery for fracture fixation, further exacerbating inflammation, leading to cytokine storm. It is imperative that such patients are informed regarding increased mortality risk during the consent and shared decision-making process.
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