Evidence map›Paper›PMID 33896683›Full record

ReviewTrends in parasitology2021

Unraveling mosquito metabolism with mass spectrometry-based metabolomics.

Thomas D Horvath, Shai Dagan, Patricia Y Scaraffia

Erratum issuedAbstract readReview
In one paragraph

Review in Trends in parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Crosstalk in the cold: host-microbe interactions in insect diapause.Annals of the Entomological Society of America · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The buzz in the field: the interaction between viruses, mosquitoes, and metabolism.Frontiers in cellular and infection microbiology · 2023
    Review
  10. Article
  11. Ornithine decarboxylase deficiency critically impairs nitrogen metabolism and survival in Aedes aegypti mosquitoes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Thomas D HorvathDepartment of Immunology and Pathology, Baylor College of Medicine, and Texas Children's Microbiome Center, Texas Children's Hospital, Houston, TX, 77030, USA.
Shai DaganIsrael Institute for Biological Research, Ness Ziona, Israel, 74100, Israel.
Patricia Y ScaraffiaDepartment of Tropical Medicine and Vector-Borne Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, 70112, USA. Electronic address: pscaraff@tulane.edu.

Funding

Mechanistic regulation of ammonia metabolism in Aedes aegypti mosquitoesR01AI146199 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI SCARAFFIA, PATRICIA YOLANDA · 2019 to 2024
$1.9M
NIAID NIH HHS R01 AI146199
6 · The paper itself

Abstract

Nearly half a million people die annually due to mosquito-borne diseases. Despite aggressive mosquito population-control efforts, current strategies are limited in their ability to control these vectors. A better understanding of mosquito metabolism through modern approaches can contribute to the discovery of novel metabolic targets and/or regulators and lead to the development of better mosquito-control strategies. Currently, cutting-edge technologies such as gas or liquid chromatography-mass spectrometry-based metabolomics are considered 'mature technologies' in many life-science disciplines but are still an emerging area of research in medical entomology. This review primarily discusses recent developments and progress in the application of mass spectrometry-based metabolomics to answer multiple biological questions related to mosquito metabolism.

Indexed as

Mass SpectrometryMetabolomicsAnimalsCulicidaeMetabolomegas chromatography–mass spectrometryliquid chromatography–mass spectrometrymetabolic pathwaysmetabolitespathogen–vector interactionsstable-label isotope tracing

Identifiers

PMID33896683
PMCPMC8282712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.