Evidence map›Paper›PMID 33896320›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Design, synthesis and

Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Alessandro DeplanoUnit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.ORCID https://orcid.org/0000-0002-8451-5831
Jessica KarlssonDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0001-8572-5841
Federica MoracaDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-1077-1971
Mona SvenssonDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Claudia CristianoDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-4806-1764
Carmine Marco MorgilloDrug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.ORCID https://orcid.org/0000-0002-6164-7647
Christopher J FowlerDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-6658-7874
Roberto RussoDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0001-5950-1617
Bruno CatalanottiDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-7532-6959
Valentina OnnisUnit of Pharmaceutical, Pharmacological and Nutraceutical Sciences, Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.ORCID https://orcid.org/0000-0002-2438-725X
Umeå University · SEUniversity of Naples Federico II · ITUniversity of Cagliari · ITMagna Graecia University · ITUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (

Indexed as

AmidesAmidohydrolasesAnalgesicsAnimalsCyclooxygenase 2Dose-Response Relationship, DrugDrug DesignEnzyme InhibitorsFatty Acid Amide HydrolasesFlurbiprofenMaleMiceMice, Inbred StrainsModels, MolecularMolecular StructureQuantum TheoryAmidesAmidohydrolasesAnalgesicsCyclooxygenase 2Enzyme InhibitorsFatty Acid Amide HydrolasesFlurbiprofenallodyniacyclooxygenaseendocannabinoidFAAH inhibitionfatty acid amide hydrolaseFlurbiprofen amideshyperalgesianon-steroidal anti-inflammatory drugs

Identifiers

PMID33896320
PMCPMC8079065
OpenAlexW3157905225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.