ArticleMolecular diversity2022
In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors.
Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- β-Lactam Potentiating Activity, Molecular Docking, and ADMET Analysis of 3-Substituted Coumarins.Current microbiology · 2025Article
- Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents.Frontiers in chemistry · 2025Article
- Fluorinated indeno-quinoxaline bearing thiazole moieties as hypoglycaemic agents targetingJournal of enzyme inhibition and medicinal chemistry · 2024Article
- Discovery of anti-phytopathogenic fungal activity of a new type of (Journal of pesticide science · 2024Article
- Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments.Scientific reports · 2024Article
- Recent Development of DNA Gyrase Inhibitors: An Update.Mini reviews in medicinal chemistry · 2024Review
- Syntheses, reactivity, and biological applications of coumarins.Frontiers in chemistry · 2024Review
- Interception of Epoxide ring to quorum sensing system in Enterococcus faecalis and Staphylococcus aureus.AMB Express · 2023Article
- Article
- Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors.ACS omega · 2023Article
- Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs.RSC medicinal chemistry · 2022Review
- Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study.Metabolites · 2022Article
- Design, Synthesis, and Antifungal Activity of Novel 1,2,4-Triazolo[4,3-Frontiers in chemistry · 2022Article
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Authors and funding
4 authors.
Funding
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Abstract
Several coumarin-containing substitute nitrogen heterocycles have recently received considerable importance due to their diverse pharmacological properties. One-pot and rapid synthesis of coumarin derivatives was achieved via reactions of acetyl-coumarin with p-chloro-benzaldehyde and malononitrile to provide compound 2-containing cyano-amine using conventional heating. Compound 2 was condensed with different carbon electrophiles triethyl orthoformate, phenyl isocyanate, carbon disulfide, benzoyl chloride, and acetyl chloride that afforded the corresponding chromene derivatives 3-17. All the newly synthesized compounds were characterized by elemental and spectroscopic evidences. All of the synthesized compounds were tested for antimicrobial activity against S. Pneumoniae, S. Epidermidis, S. Aureus, and E. coli as Gram + ve Bacteria, K. Pneumoniae, S. Paratyphi as Gram -ve Bacteria, P. Italicum, A. Fumigatus representative for Fungi. The preliminary screening results showed that most of the compounds had moderate to high activity against all tested organisms. The most potent four compounds were subjected to further investigation against E. Coli DNA gyrase and topoisomerase IV inhibitory activity, and the results showed that all of these derivatives inhibit DNA gyrase and thus cell division. Also, in silico studies were done for the most active compounds which showed good results.
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