Evidence map›Paper›PMID 33895923›Full record

ArticleDoklady. Biochemistry and biophysics2021

Influence of Surgical Trauma in the Nasal Cavity on the Expression of p53 Protein in the Hippocampus of Rats.

I V Kastyro, I V Reshetov, G V Khamidulin, S S Shilin, V I Torshin, M G Kostyaeva, V I Popadyuk, T Y Yunusov, P E Shmaevsky, K P Shalamov and 3 more

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

I V KastyroPeoples' Friendship University of Russia, Moscow, Russia. ikastyro@gmail.com.
I V ReshetovSechenov First Moscow State Medical University, Moscow, Russia.
G V KhamidulinPeoples' Friendship University of Russia, Moscow, Russia.
S S ShilinPeoples' Friendship University of Russia, Moscow, Russia.
V I TorshinPeoples' Friendship University of Russia, Moscow, Russia.
M G KostyaevaPeoples' Friendship University of Russia, Moscow, Russia.
V I PopadyukPeoples' Friendship University of Russia, Moscow, Russia.
T Y YunusovCity Clinical Hospital No. 40 of the Moscow Department of Health, Moscow, Russia.
P E ShmaevskyPeoples' Friendship University of Russia, Moscow, Russia.
K P ShalamovPeoples' Friendship University of Russia, Moscow, Russia.
A D KupryakovaPeoples' Friendship University of Russia, Moscow, Russia.
E S DoroginskayaPeoples' Friendship University of Russia, Moscow, Russia.
A D SedelnikovaPeoples' Friendship University of Russia, Moscow, Russia.
Peoples' Friendship University of Russia · RUCity Clinical Hospital · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to determine the role of the stress effect of septoplasty modeling on p53 protein expression in the hippocampus of rats under conditions of sensory olfactory deprivation. Simulation of septoplasty was carried out on 30 sexually mature male rats. A quantitative assessment of the apoptosis of neurons in the pyramidal layer of the hippocampus in the subfields CA1, CA2, CA3, and dentate gyrus (DG) on days 2, 4, and 6 after surgery was carried out. Histological sections were stained by the immunohistochemical method with antibodies to the p53 protein. An increase in the number of p53-positive neurons was noted in all subfields; the maximum increase in the number of apoptotic neurons was noted on day 4 after surgery. The stress effect of modeling septoplasty in rats, accompanied by sensory deprivation of the peripheral part of the olfactory analyzer, provoked the expression of p53 and the initiation of apoptosis mechanisms in various subfields of the hippocampus.

Indexed as

Gene Expression RegulationAnimalsHippocampusMaleNasal CavityRatsTime FactorsTumor Suppressor Protein p53Tumor Suppressor Protein p53apoptosishippocampusneuronneuronal nichep53 proteinseptoplastystress

Identifiers

PMID33895923
OpenAlexW3157939011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.