Evidence map›Paper›PMID 33895885›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Post-cardiac arrest myoclonus and in ICU mortality: insights from the Parisian Registry of Cardiac Arrest (PROCAT).

Omar Ben Hadj Salem, Matthieu Jamme, Marine Paul, Lucie Guillemet, Florence Dumas, Frédéric Pène, Jean-Daniel Chiche, Julien Charpentier, Jean-Paul Mira, Hervé Outin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Omar Ben Hadj SalemMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Matthieu JammeMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Marine PaulMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Lucie GuillemetMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Florence DumasUFR de Médecine, Paris-Descartes-Sorbonne-Paris-Cité, Paris, France.
Frédéric PèneMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Jean-Daniel ChicheMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Julien CharpentierMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Jean-Paul MiraMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.
Hervé OutinIntensive Care Unit, Poissy-Saint Germain en Laye, Centre Hospitalier Intercommunal, Poissy, France.
Eric AzabouClinical Neurophysiology and Neuromodulation Unit, Raymond Poincaré Hospital, Assistance Publique -Hôpitaux de Paris, Garches, France. eric.azabou@aphp.fr.ORCID http://orcid.org/0000-0002-9747-9972
Alain CariouMedical Critical Care Unit, Cochin Hospital, Assistance Publique -Hôpitaux de Paris, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-cardiac arrest myoclonus (PCAM) is a frequent finding in resuscitated patients after cardiac arrest (CA), with rather poor prognostic significance. In this study, we evaluated the association of PCAM within intensive care unit (ICU) mortality from a university hospital CA patients' registry.

methodsClinical data of consecutive CA survivors admitted in the intensive care unit (ICU) between January and December 2016 at the Paris Cochin University Hospital were assessed from the Parisian registry of cardiac arrest (PROCAT) and analyzed. Neurologic outcome was assessed using the Cerebral Performance Categories (CPC) scale at ICU discharge. Prevalence of PCAM and their association with mortality at ICU discharge were computed.

resultsOne hundred thirty-two (132) patients were included (73.5% males), median age of 66 years. Among them, 37 (28%) developed PCAM during their ICU stay. Only two patients with PCAM survived (5.4%). PCAM was strongly associated with mortality at ICU discharge (odds ratio 17.5 [4.2-123.2]). Sensitivity, specificity, PPV, and NPV of PCAM for prediction of death were 41%, 96%, 95%, and 46%, respectively.

conclusionPCAM was observed in nearly one-third of CA patients admitted in ICU. Patients with PCAM had a significantly higher likelihood of ICU mortality and a low likelihood of a good outcome. The prognostic value of PCAM seems rather bleak but remains nuanced and merits study in larger-scale prospective studies taking into account confounding factors.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestMyoclonusAgedFemaleHumansIntensive Care UnitsMaleProspective StudiesRegistriesRetrospective StudiesCardiac arrestMortalityMyoclonusPost-anoxic myoclonusPrognosisStatus myoclonus

Identifiers

PMID33895885
PMCPMC7670102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.